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IRF-1-mediated IFN-g enhancement of TRAIL-induced apoptosis
Park, S.Y.;Seol, J.W.;Lee, Y.J.;Kim, I.S.;Kang, H.S.;Chae, J.S.;Cho, J.H.(Chonbuk National University, Jeonju, Republic of Korea)E-mail:sypark@chonbuk.ac.kr | Kang, S.J.(National Livestock Research Institute, Cheonan, Republic of Korea)
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family and potent inducer of apoptosis. TRAIL has been shown to effectively limit tumor growth in vivo without detectable cytotoxic side effects. Interferon (IFN)-γ often modulates the anti-cancer activities of TNF family members including TRAIL. We previously reported that IFN-γ enhanced TRAIL-induced Apoptosis in HeLa cells without the unknown mechanism. In this study, we investigated whether IRF-1 involves in IFN-γ-enhanced TRAIL-induced apoptosis. We exposed HeLa cells to IFN-γ for 12 hours and then treated with recombinant TRAIL protein.
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