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Hepatic extraskeletal osteosarcoma with systemic metastasis in a dog
2013
Johnson, C., North Carolina State University ,Raleigh, USA | Kim, Y., Seoul National University, Seoul, Republic of Korea
A ten-year-old dog was presented with pancreatitis and increased hepatic enzymes. On necropsy a large firm mass was observed in the liver extending to the gall bladder. Smaller masses with similar texture were found in multiple organs including lung, stomach, pancreas, lymph nodes, omentum, and mesentery. Neoplastic cells were spindle shaped with prominent osteoid production and occasional trabeculae of woven bone. Tumor cell emboli were observed in the blood vessels and lymphatics of the omentum and stomach. Hepatic osteosarcoma with systemic metastasis is very rare and may serve to broaden the diagnostic spectrum of hepatic and pancreatic diseases in dogs.
اظهر المزيد [+] اقل [-]The recovery effect of polyacetylene constituents from Acanthopanax senticosus extracts on hepatic injury in dogs
2007
Cho, S.N. (Chungnam National University, Daejeon, Republic of Korea) | Liu, Jianzhu (Shandong Agricultural University, Taian, China) | Jun, H.K. (Chungnam National University, Daejeon, Republic of Korea) | Cho, S.W. (Chungnam National University, Daejeon, Republic of Korea) | Chang, K.S. (Chungnam National University, Daejeon, Republic of Korea) | Kim, S.J. (Chungnam National University, Daejeon, Republic of Korea) | Kim, Y.H. (Chungnam National University, Daejeon, Republic of Korea) | Yang, H.J. (Chungnam National University, Daejeon, Republic of Korea) | Kim, D.H. (Chungnam National University, Daejeon, Republic of Korea), E-mail: dhkim@cnu.ac.kr
The present study was performed to clarify the recovery effect of polyacetylene constituents from Acanthopanax senticosus ethanol extracts on CCl₄-induced acute hepatic injury in dogs. Sixteen clinically healthy dogs were divided into the control group (six dogs), and experimental group Ⅰ (three dogs), Ⅱ (three dogs) and Ⅲ (four dogs). Acute hepatic injury was induced by single intraperitoneal injection of 1 ml/kg CCl₄solution (CCl₄: olive oil = 1 : 1) after sterilization. The control group was orally administered with 10 ml of corn oil, and experimental groups Ⅰ, Ⅱ and Ⅲ were orally administered with extracts of A. senticosus at the dose of 5, 10 and 30 mg/kg in 10 ml corn oil for seven consecutive days at 24 h after CCl₄ injection.
اظهر المزيد [+] اقل [-]Primary copper-associated chronic hepatitis without copper metabolism domain containing 1 mutation in a Dalmatian: a case report
2022
Yun, S.M. | Lee, D.H. | Oh, J.M. | Chae, Y. | Yun, T.S. | Koo, Y.H. | Yang, M.P. | Kang, B.T. | Kim, H.H.
A 12-year-old intact male Dalmatian dog presented hyporexia and vomiting for 1 week. Blood analysis revealed increased liver enzyme activity. Histopathological examination of the liver confirmed chronic hepatitis with fibrosis and necrosis. Copper staining revealed marked copper accumulation (2,770 ppm; normal range, 200 to 400 ppm), prominent in the centrilobular region, and compatible with copper-associated chronic hepatitis. However, copper metabolism domain containing 1 (COMMD1) mutation predisposing to copper accumulation in the liver tissue was not identified. The dog received medications but died 1 month after first visit. This is the first case of primary copper-associated hepatitis without COMMD1 mutation in a Dalmatian dog in South Korea.
اظهر المزيد [+] اقل [-]Primary hepatic hemangiosarcoma (HSA) in a Schnauzer dog
2009
Kang, M.H., Konkuk University, Seoul, Republic of Korea | Heo, R.Y., Konkuk University, Seoul, Republic of Korea | Park, H.M., Konkuk University, Seoul, Republic of Korea
A 6-year-old, neutered male, Schnauzer was presented with a one year history of weight loss and exercise intolerance. Physical examination revealed abdominal distention and ecchymosis on the abdominal skin. CBC and serum chemistry profiles revealed anemia and increased serum liver enzymes. Postmortem examination revealed primary hepatic hemagiosarcoma. The tumor had extended to the mesentery and diaphragm, but distant metastasis was not found. This case report describes primary hepatic hemangiosarcoma which is very rare in a dog.
اظهر المزيد [+] اقل [-]Toxicological effects of perfluorooctanoic acid in rats
2008
Kim, Y.H. (Chungnam National University, Daejeon, Republic of Korea) | Cho, E.S. (Chungnam National University, Daejeon, Republic of Korea) | Kim, A.Y. (Chungnam National University, Daejeon, Republic of Korea) | Kim, S.H. (Chungnam National University, Daejeon, Republic of Korea) | Park, M.S. (Chungnam National University, Daejeon, Republic of Korea) | Cho, S.W. (Chungnam National University, Daejeon, Republic of Korea) | Ryu, S.Y. (Chungnam National University, Daejeon, Republic of Korea) | Jung, J.Y. (Chungnam National University, Daejeon, Republic of Korea) | Son, H.Y. (Chungnam National University, Daejeon, Republic of Korea), E-mail: hyson@cnu.ac.kr
Perfluorooctanoic acid (PFOA), a member of the perfluoroalkyl acids that have wide commercial applications, is persistent organic pollutants widely spread throughout the environment and human population. But little is known about the adverse biological effects of the PFOA. In the present study, the toxicological effects of PFOA were investigated in rats. Sprague-Dawley rats (N = 10 in each group) were orally administered with PFOA in drinking water for 4 weeks (0, 100, 200, or 400 ppm in male, and 0, 200, 400, or 800 ppm in female). These female rats given 800 ppm died during the study. PFOA treatment decreased the body weight gain and increased the liver weights in both genders. Serum biochemical investigations revealed significant increases in the aspartate aminotransferase, alanine transaminase, alkaline phosphatase, blood urea nitrogen, total cholesterol, and total bilirubin in male but in female. Serum estradiol (E2) levels were increased in all treated in all treated rats. Histopathologically, hepatocellular hypertrophy around central vein was noted in the liver of treated rats. No significant histopathological change were noted in other organs. In conclusion, PFOA induced toxicological changes in the liver and increased serum E2 level which was not related to histopathological changes of endocrine and reproductive system.
اظهر المزيد [+] اقل [-]Effects of forskolin on secrtion of insulin like growth factor-1 in the perfused rat liver model
1999
Kang, C.W. | Lee, H.I. (Chonbuk National University, Chonju (Korea Republic). Bio-Safety Research Institute) | Lee, D.Y. (Chonbuk National University, Chonju (Korea Republic). Department of Pediatrics, Medical School)
The insulin-like growth factor-I(IGF-I) is an important metabolic factor involved in cell growth and metabolism. Although secretion of IGF-I in rat liver is regulated by growth hormone, the effects of forskolin, adenylate cyclase activator, on secretion of IGF-I have not been reported. Therefore, a modified perfused rat liver model was used to investigate the regulatory effects of forskolin on IGF-I secretion in this experiment. The results were summerized as follows: 1. Modified perfused rat liver model was not changed to aspartate aminotransferase(AST), alanine aminotransferase(ALT) and lactic dehydrogenase(LDH) secretion in time. 2. The IGF-I secretion in hepatic cell was increased by forskolin(10-5, 10-6 and 10-7M) in a dose-dependent manner as compared with those of the controls, and significantly increased by 10-5 and 10-6M forskolin(p0.05). 3. Secretion of glucose in hepatic cell significantly was decreased by 10-5M forskolin as compared with those of controls(p0.05). These results suggest that forskolin may be involved in the regulation of IGF-I secretion in the perfused rat liver.
اظهر المزيد [+] اقل [-]Korean red ginseng prevents ethanol-induced hepatotoxicity in isolated perfused rat liver
2011
Park, H.M., Chonbuk National University, Jeonju, Republic of Korea | Kim, S.J., Chonbuk National University, Jeonju, Republic of Korea | Go, H.K., Chonbuk National University, Jeonju, Republic of Korea | Kim, G.B., Chonbuk National University, Jeonju, Republic of Korea | Kim, S.Z., Chonbuk National University, Jeonju, Republic of Korea | Kim, J.S., Chonbuk National University, Jeonju, Republic of Korea | Kang, H.S., Chonbuk National University, Jeonju, Republic of Korea
Alcohol abuse and its medical and social consequences are a major health problem in many areas of the world. Korean red ginseng (KRG) has been traditionally used for the treatment of liver disease. This study was conducted to evaluate the hepatoprotective effects of KRG against hepatotoxicity in Sprague-Dawley rats treated with ethanol (EtOH). Administration of EtOH for 20 days induced significant changes in serum biochemical parameters (aspartate aminotransferase, alanine transaminase, and glucose) accompanied by histological changes in the liver tissue. Treatment with KRG prior to administration of EtOH inhibited the EtOH-induced biochemical and histological changes of the liver. In perfused rat livers, administration of EtOH caused an increase in lactate dehydrogenase (LDH) release into the perfusate and activated the pro-apoptotic Bax protein but inhibited the anti-apoptotic Bcl-2 protein. Pretreatment with KRG prior to administration of EtOH decreased the EtOH-induced LDH release and inhibition of Bcl-2 protein. These results suggest that KRG exerts anti-apoptotic effects and alleviated EtOH-induced liver injury in rats.
اظهر المزيد [+] اقل [-]Diethylnitrosamine-induced hepatic tumorigenesis in rats 3. Electron microscopic observaton of liver tissue
1999
Kwak, S.D. | Kim, C.S. | Koh, P.O. | Yang, J.H. | Seo, D.L. (Gyeongsang National University, Chinju (Korea Republic). Institute of Animal Medicine, College of Veterinary Medicine)
The study was designated to investigate the electron microscopic findings following diethylnitrosamine (DEN) treatment in rats. Forty four male (Srague Dawley) rats were continuously given water containing 0.01% DEN for 13 weeks and livers of five rats with more tumor lesions at 16 and 17 weeks after initial treatment were used as EM materials. In transmission electron microscopic findings, most small-sized hepatocytes were active cells containing large mount of organelles, but light (pale staining) hepatocyte among small-sized hepatocytes were injured cells containg disorganized organelles. Tumor cells among small-sized hepatocytes were irregularly arranged and have ;leomorphic nuclei containing electron dense chromatin but the organelles in cytoplasm were swelled. Large-sized hepatocytes were active cells with condensed chromatin but the cytoplasm of these cells were pale due to be injured and dilated organelles. Dark hepatocytes were apoptotic cells with homogenous pyknotic nuclei and cytoplasm, and the cytoplasm of these cells contained dilated smooth endoplasmic reticulum (sER) but these sER were non-vesiculated. Cholangiocarninoma cells were crowed and were pale by far less number of organelles in cytoplasm and nuclei. In scanning electron microscopic findings, the lumens of portal veins, bile canaliculi, bile ductules, bile ducts and sinusoids were dilated and have irregular folded inner surface by protruded parenchyma.
اظهر المزيد [+] اقل [-]Pathological studies on the hepatic fibrosis induced by Capillaria hepatica
1998
Shin, E.K. | Han, J.H. (Kangwon National University, Chunchon (Korea Republic). Department of Veterinary Medicine)
Studies on the laboratory animal modelling of atheroosclerosis and the preventive mechanisms of dietary fiber against atheroosclerosis
1993
Kim, H.W. | Lee, Y.S. | Lee, H.S. | Shin, K.S. | Lim, C.H. (Seoul National University, Suwon (Korea Republic). College of Veterinary Medicine)