The aim of this study was to compare serum nitrotyrosine concentrations in healthy dogs with those in dogs with myxomatous mitral valve disease (MMVD). Fifty client-owned dogs were included in this study. Based on echocardiographic results, dogs were categorized into healthy (control), mild-, moderate-, and severe-MMVD groups. Serum nitrotyrosine concentrations were determined from enzyme-linked immunosorbent assays. No significant difference between control dogs and dogs with mild MMVD was detected (p = 0.31). However, dogs with moderate MMVD had significantly higher serum concentrations of nitrotyrosine (p = 0.04) than that in controls, and dogs with severe MMVD had significantly lower serum concentrations of nitrotyrosine (p = 0.03) than that in moderate MMVD dogs. There were negative correlations in the association of serum nitrotyrosine with age (n = 30, R2= 0.067, p = 0.27), left atrial-to-aortic root diameter ratio (n = 30, R2= 0.02, p = 0.57), and platelet count (n = 30, R2= 0.39, p = 0.003); however, only the platelet correlation was significant. Among dogs with MMVD, there was no significant difference in serum nitrotyrosine concentration between males and females. The results of this study suggest that tyrosine nitration end-products might be potential biomarkers for the detection of MMVD in dogs.

Analysis of data on distribution of clinicopathologic symptoms of rhinotracheitis, parainfluenza-3, bovine viral diarrhoea, clamidiosis, rhinosyncytial virus, adenovirus diseases, rotaviral diseases, coronavirus infections of cattle, viral transmissible gastroenteritis, and respiratory reproductive syndrome of swine, rinderpest, rabies and Aujesky disease of agricultural animals in the conditions of the Republic of Belarus was realized. There were given descriptions of diagnostic tests and vaccines for disease prevention used in Belarus and other countries. Treatment regimen and methods and other elements of prophylaxis were presented. There was given an analysis of prophylactic efficiency of produced medicine drugs

The realized studies of an experimental series of inactivated vaccine showed that the developed biological preparation made it possible to achieve high preventive efficiency in the conditions of cows heavy with calves for the creation in newborn calves the expressing immunity after milk feeding in the first hours of their life. As a result realized in the conditions of the Republic of Belarus production experiment of emulsified vaccine against rotavirus infection and colibacillosis of cattle in animal breeding farms of different regions of the Republic the prophylactic efficacy of a developed vaccine made up 97,9-98,9%. Research results showed that the developed inactivated vaccine caused at the immunizated animals the formation of specific antibodies at a higher level in comparison with other analyzed national and foreign analogue preparations.

There were presented data on etiology, specific prophylaxis and treatment of the most widespread infectious diseases of fishes in the Republic of Belarus: aeromonosis, pseudomonosis, swim bladder inflammation (air bladder disease), viral branchionecrosis. For the preparation of highly efficient specific medical and veterinary preparations it was recommended during the outbreaks of fish diseases to allocate the local pathogens on the basis of which it was recommended to produce vaccines both for perinatal and immersion administration for their wide use both for commodity fishes and for different ages and categories

Analysis of the epizootological situation in infectious diseases in the world and the Republic of Belarus was presented. The prevention and eradication control strategy of mentioned diseases in Belarus was defined. In Belarus there was stated no cases of special danger infectious diseases of cattle: bovine spongiform encephalopathy; highly pathogenic poultry flu; aphthous fever; since 1982 - Bang's disease; since 1980 - Newcastle disease; since 1999 – anthrax. Preventive maintenance of 30 infectious diseases was based on application of specific prophylaxis.

Results of serological examinations of blood serum of sheep on revelation of virus respiratory infections (parainfluenza-3, adenovirus and respiratory syncytial) realized in the conditions of the Kyrgyz Republic were presented. Research results showed that in farm and peasant farm holdings of all studied districts of the Kyrgyz Republic of three types of pneumo viral infections simultaneously give high levels of antibody titers in relation to parainfluenza-3 – 1:128, adenovirus – 1:32, respiratory syncytial infection – 1:16. In some districts sheep population was diseased only by parainfluenzal infection in relation with titer of specific antibodies 1:256

Definition of quality parameters and chemical composition of feeds, evaluation their nutritional value and composing on this basis optimal rations for high productive animals are the most significant conditions for their health and production. More often metabolism disorders registers in the conditions of intensive animal production, at high dairy efficiency and intensive fattening. At animals at disorder of key parameters of technology (unbalanced feeding, hypodynamia, lack of insolation) is broken metabolism, decreases natural resistance, goes down quality of production that conducts to disease, premature culling and to the compelled slaughter of animals. On frequency these diseases occupy on the average 10% from all noncontagious diseases, and on dairy complexes with industrial technology and in specialized feeding economy at intensive cultivation on their share it is necessary over 30% of a noncontagious pathology. Today the control of rations on such indicators, as dry matter level, quantity of exchange energy, the maintenance of a crude and digested protein, amino acids, sugars, starch, cellulose, fat, macro-and microelements, vitamins, and also sugar-energy-protein and calcium-phosphoric parities, acid-base balance has got special value. The lack of those or other nutrients causes infringement of a clinical condition of animals and reduces their efficiency. Among the most widespread diseases of the animals registered in animal industry: cattle ketosis, osteodystrophy, endemic struma, hypomagnesiemia tetany, pasturable tetany, microelementosis, hypovitaminoses A and Е.

There was studied the efficiency of a preparation Aquamed and 0,037% sodium hypochlorite at calve bronchopneumonia and their comparative characteristic. Besides the main task decision - elimination of the reasons of animal disease and occurrence of exogenic and endogenic intoxication - application of the preparations normalizing functioning of bodies and systems, neutralized and deducing of organism alien substances, use of the substances modelling natural mechanisms of increase of protective forces is required. One of such perspective means is use of the solution Aquamed received by electrochemical method on an installation Aquamed. Analogue to the solution Aquamed is the sodium preparation hypochlorite 0,037% which received on the installations EDO-4. However application of the given preparation is limited to high cost of the device for its manufacture (EDO-4). This device is made in Russian Federation, has a high cost that creates certain problems with its purchase by economy of Belarus. Therefore in Belarus (Gomel) manufacture of the domestic device for electroactivation of water and reception of electroactivated solutions Aquamed is adjusted. The given working out is protected by the patent for the invention. Analyzing results, it is possible to draw a conclusion, that the preparation Aquamed renders positive therapeutic effect at calve bronchopneumonia control. Application of the installation Aquamed is more accessible and cheap way of preparation and application of solutions of sodium hypochlorite, along with analogues. | Целью исследования было изучение терапевтической эффективности препарата Аквамед и натрия гипохлорита 0,037% при бронхопневмонии телят и их сравнительная характеристика. Помимо решения главной задачи - недопущения и устранения причин заболеваемости животных и возникновения у них экзогенной и эндогенной интоксикации организма - требуется применение препаратов, нормализующих функционирование органов и систем, нейтрализующих и выводящих из организма чужеродные вещества, использование веществ, моделирующих естественные механизмы повышения защитных сил. Одним из таких перспективных средств является использование раствора Аквамед, полученного электрохимическим путем на установке Аквамед. Аналогом раствору Аквамед является препарат натрия гипохлорит 0,037%, который получают на установках ЭДО-4. Однако применение данного препарата ограничивается высокой стоимостью аппарата для его производства (ЭДО-4). Этот аппарат производится в Российской Федерации, имеет высокую стоимость, что создает определенные проблемы с его закупкой хозяйствами Беларуси. Поэтому в Республике Беларусь (г.Гомель) налажено производство отечественного аппарата для электроактивации воды и получения электроактивированных растворов Аквамед. Данная разработка защищена патентом на изобретение. Анализируя результаты, можно сделать вывод, что препарат Аквамед оказывает положительный терапевтический эффект при борьбе с бронхопневмонией. Применение установки Аквамед является более доступным и дешевым способом приготовления и применения растворов натрия гипохлорита, наряду с аналогами.

In the conditions of the Republic of Belarus there was determined the therapeutic efficacy of combined application of a complex antibacterial veterinary drug (containing lincomycin and spectinomycin) and Trivitim for the treatment of calves with respiratory diseases. In course of the study of 12 1-1,5 month old calves with respiratory diseases there were analyzed the hematological blood indexes, white blood cell differential and content of total protein in blood serum before the beginning of treatment and on the seventh and fourteenth days after beginning treatment. Research results showed that application the antibacterial veterinary drug in complex therapy with Trivitim in treatment of calves proved to be efficient. Their administration shortened the terms of recovery and prevented animal death as well as promoted the normalization of hematological and biochemical blood indexes.

In the conditions of the Republic of Belarus there was determined the influence of lactulose of the clinical state of weanling piglets, as well as analysis of its preventive and therapeutic efficacy. For the experimental group of piglets in course of 5 days before weaning the lactulose for administrated daily in combination with feed in course of 5 days in dose of 0,002 gram per kilogram of live weight. In 3-5 days after weaning the diarrhea was stated in 4,1% of experimental piglets. The clinically evident efficiency of application of the synthetic disaccharide was showed in lowering of disbacteriosis level in weaning piglets on 33,7%. Besides, there was analyzed the therapeutic efficacy of lactulose for weaning piglets diseased with gastroenteritis. They were administrated lactulose in dose of 0,03 grams per kilogram of live weight once a day after feeding in course of 7 days. Haematologic and biochemical blood indexes of experimental and control groups of piglets were analyzed. Research results showed that application of lactulose promoted the creation of optimal conditions for beneficial microflora, stimulated its reproduction, suppressed the development of opportunistic pathogens.