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Artemisia capillaris Thunb. inhibits melanin synthesis activity via ERK-dependent MITF pathway in B16/F10 melanoma cells
2018
Evelyn Saba, Kyungpook National University, Daegu, Republic of Korea | Oh, M.J., Kyungpook National University, Daegu, Republic of Korea | Lee, Y.Y., Kyungpook National University, Daegu, Republic of Korea | Kwak, D., Kyungpook National University, Daegu, Republic of Korea | Kim, S., Gyeongsang National University, Jinju, Republic of Korea | Rhee, M.H., Kyungpook National University, Daegu, Republic of Korea
Genus Artemisia occurs as a hardy plant and has a wide range of culinary and medicinal features. In this study, we aimed to describe the melanin inhibitory activity of one Artemisia species, i.e., Artemisia capillaris Thunb. Ethanol extracts of fermented Artemisia capillaris (Art.EtOH.FT) and non-fermented Artemisia capillaris (Art.EtOH.CT) were tested for their ability to inhibit tyrosinase activity and melanin pigmentation. Both extracts showed dose-dependent inhibition against alpha-melanocyte stimulating hormone−stimulated melanin formation and tyrosinase activity, without cytotoxicity. At 100 ㎍/mL, both extracts showed greater inhibition than kojic acid, the positive control. Protein expressions of microphthalmia-associated transcription factor (MITF), tyrosinase (TYR), tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2) at the transcriptional level were determined by using real-time and semi-quantitative polymerase chain reaction. To complete the mechanistic study, presences of upstream elements of MITF, the phosphorylated-extracellular signal-regulated kinase (p-ERK), and phosphorylated−mitogen-activated protein kinase kinase (p-MEK) were confirmed by using western blot analysis. Expressions of p-TYR, p-TRP-1 and p-TRP2, downstream factors for p-ERK and p-MITF, were translationally inhibited by both extracts. Art.EtOH.FT induced more potent effects than Art.EtOH.CT, especially signal transduction effects. In summary, Artemisia capillaris extracts appear to act as potent hypopigmentation agents.
اظهر المزيد [+] اقل [-]Effects of forskolin on secrtion of insulin like growth factor-1 in the perfused rat liver model
1999
Kang, C.W. | Lee, H.I. (Chonbuk National University, Chonju (Korea Republic). Bio-Safety Research Institute) | Lee, D.Y. (Chonbuk National University, Chonju (Korea Republic). Department of Pediatrics, Medical School)
The insulin-like growth factor-I(IGF-I) is an important metabolic factor involved in cell growth and metabolism. Although secretion of IGF-I in rat liver is regulated by growth hormone, the effects of forskolin, adenylate cyclase activator, on secretion of IGF-I have not been reported. Therefore, a modified perfused rat liver model was used to investigate the regulatory effects of forskolin on IGF-I secretion in this experiment. The results were summerized as follows: 1. Modified perfused rat liver model was not changed to aspartate aminotransferase(AST), alanine aminotransferase(ALT) and lactic dehydrogenase(LDH) secretion in time. 2. The IGF-I secretion in hepatic cell was increased by forskolin(10-5, 10-6 and 10-7M) in a dose-dependent manner as compared with those of the controls, and significantly increased by 10-5 and 10-6M forskolin(p0.05). 3. Secretion of glucose in hepatic cell significantly was decreased by 10-5M forskolin as compared with those of controls(p0.05). These results suggest that forskolin may be involved in the regulation of IGF-I secretion in the perfused rat liver.
اظهر المزيد [+] اقل [-]Biochemical properties and cultural characteristics of Escherichia coli isolated from chickens
1990
Woo, Y.K. | Kim, K.S. (Rural Development Administration, Anyang (Korea Republic). Veterinary Research Institute) | Kim, B.H. (Kyungpook National University, Taegu (Korea Republic). College of Veterinary Medicine)
Biochemical properties and antimicrobial drug susceptibility of Erysipelothrix rhusiopathiae isolated from the cases of acute septicemic swine erysipelas
1990
Baek, Y.S. | Cho, G.J. | Kim, B.H. (Kyungpook National University, Taegu (Korea Republic). College of Veterinary Medicine)