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Anti-influenza properties of herbal extract of Althaea rosea in mice
2018
Kim, M.S., R and D Division, VITABIO Inc., Daejeon, Republic of Korea | Kiramage Chathuranga, Chungnam National University, Daejeon, Republic of Korea | Kim, H., R and D Division, VITABIO Inc., Daejeon, Republic of Korea | Lee, J.S., Chungnam National University, Daejeon, Republic of Korea | Kim, C.J., Chungnam National University, Daejeon, Republic of Korea
Althaea rosea has been used in traditional Chinese medicine to treat numerous diseases, but no studies have investigated its anti-influenza properties to date. In this study, we investigated the anti-influenza effects of Althaea rosea. BALB/c mice orally pretreated with Althaea rosea (200 킠, 0.1 mg/mL concentration in phosphate-buffered saline) and followed by infection of influenza A virus nasally showed higher survivability and lower lung virus titer against divergent subtypes of influenza A virus infection. We also found that oral administration of Althaea rosea elicited antiviral innate immune responses in serum, bronchoalveolar lavage fluid, small intestinal fluid, and the lungs. Taken together, these findings suggest that aqueous extracts of Althaea rosea are a potential candidate for use as an anti-influenza drug.
اظهر المزيد [+] اقل [-]Long-circulating and target-specific distributions of cyanine 5.5-labeled hyaluronic acid nanoparticles in mouse organs during 28 days after a single administration
2018
Yun, T.S., Chungbuk National University, Cheongju, Republic of Korea | Chunmei Lin, Jilin Agricultural University, Changchun, Republic of Korea | Yon, J.M., Chungbuk National University, Cheongju, Republic of Korea | Park, S.G., Chungbuk National University, Cheongju, Republic of Korea | Gwon, L.W., Chungbuk National University, Cheongju, Republic of Korea | Lee, J.G., Chungbuk National University, Cheongju, Republic of Korea | Baek, I.J., University of Ulsan College of Medicine, Seoul, Republic of Korea | Nahm, S.S., Konkuk University, Seoul, Republic of Korea | Lee, B.J., Chungbuk National University, Cheongju, Republic of Korea | Yun, Y.W., Chungbuk National University, Cheongju, Republic of Korea | Nam, S.Y., Chungbuk National University, Cheongju, Republic of Korea
Although hyaluronic acid (HA) has been developed as a nanoparticle (NP; 320-400 nm) for a drug delivery system, the tissue targeting efficacy and the pharmacokinetics of HA-NPs are not yet fully understood. After a dose of 5 mg/kg of cyanine 5.5-labeled HA-NPs or HA-polymers was intravenously administrated into mice, the fluorescence was measured from 0.5 h to 28 days. The HA-NPs fluorescence was generally stronger than that of HA-polymers, which was maintained at a high level over 7 days in vivo, after which it gradually decreased. Upon ex vivo imaging, liver, spleen, kidney, lung, testis and sublingual gland fluorescences were much higher than that of other organs. The fluorescence of HA-NPs in the liver, spleen and kidney was highest at 30 min, where it was generally maintained until 4 h, while it drastically decreased at 1 day. However, the fluorescence in the liver and spleen increased sharply at 7 days relative to 3 days, then decreased drastically at 14 days. Conversely, the fluorescence of HA-polymers in the lymph node was higher than that of HA-NPs. The results presented herein may have important clinical implications regarding the safety of as self-assembled HA-NPs, which can be widely used in biomedical applications.
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