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Histopathological, immunohistochemical, and parasitological studies on pathogenesis of Coenurus cerebralis in sheep النص الكامل
2018
Rahsan, Yilmaz | Nihat, Yumusak | Bestami, Yilmaz | Adnan, Ayan | Nuran, Aysul
Histopathological, immunohistochemical, and parasitological studies on pathogenesis of Coenurus cerebralis in sheep النص الكامل
2018
Rahsan, Yilmaz | Nihat, Yumusak | Bestami, Yilmaz | Adnan, Ayan | Nuran, Aysul
This study consisted in histopathological and immunohistochemical examinations of the central nervous system of 15 sheep suspected of infection with Coenurus cerebralis. The sheep displayed compulsive circling and were submitted for necropsy in 2012–2016. Species identification was made on the basis of the PCR analysis and parasitological examination of the cysts. Coenurus cerebralis cysts were detected only in the cerebral tissue of 13 sheep and in the cerebral and cerebellar tissues of 2 animals. Out of the 33 parasite cysts, most (21.21%) were located in the right and left frontal lobes of the cerebrum. The largest cyst measured 6 × 5 cm and the smallest cyst was 2 × 2 cm in size. The highest and lowest numbers of scolices were 55 and 21, and the number of rostellar hooks ranged between 22 and 30. Histopathological examination revealed the presence of typical parasitic granulomatous inflammatory foci. Immunohistochemical staining showed that most common in the periphery of the parasite cysts were, in descending order by cell number, GFAP, CD163, CD3, and CD79α-positive cells. The study confirms the role of cellular defence mechanisms in the pathogenesis of Coenurus cerebralis infection in sheep.
اظهر المزيد [+] اقل [-]Histopathological, immunohistochemical, and parasitological studies on pathogenesis of Coenurus cerebralis in sheep النص الكامل
2018
Rahsan Yilmaz | Nihat Yumusak | Bestami Yilmaz | Adnan Ayan | Nuran Aysul
This study consisted in histopathological and immunohistochemical examinations of the central nervous system of 15 sheep suspected of infection with Coenurus cerebralis. The sheep displayed compulsive circling and were submitted for necropsy in 2012–2016.
اظهر المزيد [+] اقل [-]Magnetic resonance imaging of the brain and skull of sheep with cerebral coenurosis النص الكامل
2012
Manunta, Maria L. | Evangelisti, Maria A. | Burrai, Giovanni P. | Columbano, Nicolo | Ligios, Ciriaco | Varcasia, Antonio | Scala, Antonio | Passino, Eraldo Sanna
Objective: To determine MRI characteristics of the skulls and brains of sheep with chronic cerebral coenurosis (CC) caused by naturally acquired Taenia multiceps infection. Animals: 33 sheep with CC and 10 healthy control sheep. Procedures: Sheep underwent MRI of the head. Volumes of the cranial cavity and rostral and caudal fossas of the cranial cavity were determined. For CC-affected sheep, the number, location, and volume of T multiceps cysts were determined and the percentage volumes of cysts in the cranial cavity and rostral and caudal fossas of the cranial cavity were calculated. Focal and diffuse abnormalities of cranial bones in CC-affected sheep were identified. Brain edema and hemorrhage and signs of increased cranial pressure (ICP) in MRI images were determined. Results: Volumes of the cranial cavity and rostral and caudal fossas of the cranial cavity were significantly larger for CC-affected sheep versus healthy control sheep. Total volumes of cysts ranged from 4.40% to 46.93% in cranial cavities of sheep, 4.12% to 51.53% in rostral fossas of cranial cavities of sheep, and 15.24% to 68.30% in caudal fossas of cranial cavities of sheep. Moderate to severe diffuse cranial bone abnormalities and signs of increased ICP in MRI images were detected in 21 and 24 sheep, respectively, and were positively correlated with cyst volumes. Conclusions and Clinical Relevance: Results suggested that cranial cavity volume and morphological abnormalities can be detected in sheep with CC. These changes may reflect abnormalities in ossification of the cranial bones secondary to chronically increased ICP caused by development of T multiceps cysts.
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