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The in vitro biologic effects of T-2 mycotoxin on the immune response of mice was undertaken. Twenty nanograms of toxin abrogated the immune response to the T-dependent antigen sheep RBC, whereas a partial response was observed when 2 ng was used. Analysis of cell culture viabilities indicated that cell death occurred with toxin doses that conincided with the diminished immune responses. A similar decreased response was observed against the T-independent antigen, TNP-lipopolysaccharide, indicating toxic effects on both B and T lymphocyte populations. Delay of toxin administration as much as 116 hours of the 120-hour incubation period still resulted in a substantially diminished immune response, indicating the toxin acts on both the afferent and efferent immune systems. Equal effects were observed for mice of the b, d, and k haplotype, indicating no apparent strain variability in sensitivity to T-2 mycotoxin effects. These results indicated that T-2 mycotoxin can modulate the immune response, and that this modulation is attributable to direct toxic effects on the cells of the immune system.

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mycotoxins spleen cells mycotoxins mice immunology cultured inbred balb c drug effects administration & dosage hemolytic plaque technique inbred c57bl ...

National Agricultural Library - United States of America

Case-control study of risk factors associated with nosocomial Salmonella krefeld infection in dogs

1988

Uhaa, I.J. | Hird, D.W. | Hirsh, D.C. | Jang, S.S.

In a case-control study of risk factors associated with an episode of nosocomial Salmonella krefeld infection in dogs at the veterinary medical teaching hospital, data on 20 case dogs and 75 control dogs were obtained by review of hospital records. Univariate and multivariate statistical analyses were carried out for possible risk factors for infection to obtain odds of Salmonella krefeld isolation, given exposure to each risk factor of interest. Compared with control dogs, case dogs were 11.9 times more likely to have been fed rice, 7 times more likely to have had radiography done, 10.2 times more likely to have been a resident in ward 2, 5.6 times more likely to have been given antimicrobial agents orally, 11.3 times more likely to have been given antimicrobial agents parenterally, and 37.9 times more likely to have been given antimicrobial agents orally and parenterally (P less than 0.05).

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antimicrobial agents salmonella radiography microbiology age animal transmission female salmonella infections veterinary hospitalization dog diseases ...

National Agricultural Library - United States of America

A new cestode, Raillietina (Raillietina) oligocapsulata n. sp., and R. (R.) demerariensis (Daniels, 1895) from Venezuelan mammals

1988

Sato, H. (Hokkaido Univ., Sapporo (Japan). Faculty of Veterinary Medicine) | Okamoto, M. | Ohbayashi, M. | Basanez, M.G.

raillietina lagomorfos lagomorphe especies nuevas hosts new species venezuela/ anatomie animale venezuela/ anatomia animal huespedes venezuela/ animal morphology hote espece nouvelle ...