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Human exposure to organochlorine, pyrethroid and neonicotinoid pesticides: Comparison between urban and semi-urban regions of India
2021
Anand, Niharika | Chakraborty, Paromita | Ray, Sujata
In developing countries, urban areas may be at greater risk of pesticide exposure compared to semi-urban agricultural regions. To investigate this, concentrations of selected pesticides were measured in 81 human milk samples collected in urban Kolkata and semi-urban Nadia in West Bengal, India. Three classes of pesticides were investigated – legacy organochlorines and emerging pyrethroids and neonicotinoids. The average concentration of the majority of the chemicals (DDT, its metabolites, HCH isomers, bifenthrin, endosulfan), showed a clear urban > semi-urban trend. Compared with previous measurements in other Indian cities and developing nations, current HCH and DDT concentrations in urban Kolkata were high. These chemicals were detected in 100% of the samples in both the urban and the semi-urban region. Also in both regions, the Estimated Daily Intake of DDTs, HCHs, aldrin, dieldrin and the pyrethroid bifenthrin for breastfed infants exceeded the Tolerable Daily Intake in a number of samples. Three pyrethroids were detected in human milk samples in India for the first time. This indicates a shift in the usage pattern of pesticides in India from organochlorines to pyrethroids. These findings may be used to drive targeted regulation of pesticides in developing countries with similar histories of pesticide use.
اظهر المزيد [+] اقل [-]Mycotoxin occurrence in breast milk and exposure estimation of lactating mothers using urinary biomarkers in São Paulo, Brazil
2021
Coppa, Carolina F.S.C. | Cirelli, Amanda C. | Gonçalves, Bruna L. | Barnabé, Eliana M.B. | Petta, Tânia | Franco, Larissa T. | Javanmardi, Fardin | Khaneghah, Amin Mousavi | Lee, Sarah H.I. | Corassin, Carlos H. | Oliveira, Carlos A.F.
In this study, the occurrence of aflatoxins (AFs), fumonisins (FBs), ochratoxin A (OTA), deoxynivalenol (DON), zearalenone (ZEN) and some of their metabolites were assessed in breast milk and urine of lactating women (N = 74) from Pirassununga, São Paulo, Brazil. Exposure estimations through urinary mycotoxin biomarkers was also performed. Samples were collected in four sampling times (May and August 2018, February and July 2019) and analyzed by liquid chromatography coupled to tandem mass spectrometry. Aflatoxin M₁ (AFM₁) was not detected in breast milk. However, two samples (3%) presented FB₁ at 2200 and 3400 ng/L, while 4 samples (5%) had OTA at the median level of 360 ng/L. In urine, AFM₁ and aflatoxin P₁ (AFP₁) were found in 51 and 11% of samples, respectively (median levels: 0.16 and 0.07 ng/mg creatinine, respectively). Urinary DON (median level: 38.59 ng/mg creatinine), OTA (median level: 2.38 ng/mg creatinine) and ZEN (median level: 0.02 ng/mg of creatinine) were quantified in 18, 8 and 10% of the samples, respectively. Mean probable daily intake (PDI) values based on urinary biomarkers were 1.58, 1.09, 5.07, and 0.05 μg/kg body weight/day for AFM₁, DON, OTA, and ZEN, respectively. Although a low mycotoxin occurrence was detected in breast milk, the PDI for the genotoxic AFs was much higher than those reported previously in Brazil, while PDI values obtained for OTA and DON were higher than recommended tolerable daily intakes. These outcomes warrant concern on the exposure of lactating women to these mycotoxins in the studied area.
اظهر المزيد [+] اقل [-]A pilot study on health risk assessment based on body loadings of PCBs of lactating mothers at Taizhou, China, the world's major site for recycling transformers
2017
Man, Yu Bon | Chow, Ka Lai | Xing, Guan Hua | Chan, Janet Kit Yan | Wu, Sheng Chun | Wong, Ming Hung
Our early study reported an extraordinarily high Estimated Daily Intake (EDI) of PCBs of lactating mothers from Taizhou, Zhejiang Province, China (based on a food consumption survey and food basket analysis). The EDI well exceeded the intake limit stipulated by FAO/WHO 70 pg TEQ/kg body weight (bw)/month. The present pilot study provided further information on PCBs body burden in lactating mothers of Taizhou. The total PCBs detected in human milk, placenta and hair samples of these lactating mothers were 363 ng/g lipid, 224 ng/g lipid, and 386 ng/g dry wt. Respectively, three times higher than those samples collected from the reference site (Lin'an). Compared with the previous reported values in the 3rd WHO coordinated study, Taizhou topped the list of 32 countries/regions with regards to WHO-PCB-TEQ values of milk samples, which could be attributed to the relatively higher level of PCB-126 derived from electronic waste. In addition, the corresponding EDI of PCBs of Taizhou mothers (12.9 pg WHO-PCB-TEQ/kg bw/day) and infants (438 pg WHO-PCB-TEQ/kg) were derived from individual congener levels in human milk. The results were also higher than the tolerable daily intakes recommended by WHO (1–4 pg WHO-TEQ/kg bw/day) by 3 and 110 times, for mothers and infants, respectively. A more intensive epidemiological study on the potential health effects of e-waste recycling activities affecting both workers and residents seems to be of top priority, based on findings of this pilot study.
اظهر المزيد [+] اقل [-]Serum biomarkers of polyfluoroalkyl compound exposure in young girls in Greater Cincinnati and the San Francisco Bay Area, USA
2014
Pinney, Susan M. | Biro, Frank M. | Windham, Gayle C. | Herrick, Robert L. | Yaghjyan, Lusine | Calafat, Antonia M. | Succop, Paul | Sucharew, Heidi | Ball, Kathleen M. | Kato, Kayoko | Kushi, Lawrence H. | Bornschein, Robert
PFC serum concentrations were measured in 6–8 year-old girls in Greater Cincinnati (GC) (N = 353) and the San Francisco Bay Area (SFBA) (N = 351). PFOA median concentration was lower in the SFBA than GC (5.8 vs. 7.3 ng/mL). In GC, 48/51 girls living in one area had PFOA concentrations above the NHANES 95th percentile for children 12–19 years (8.4 ng/mL), median 22.0 ng/mL. The duration of being breast fed was associated with higher serum PFOA at both sites and with higher PFOS, PFHxS and Me-PFOSA-AcOH concentrations in GC. Correlations of the PFC analytes with each other suggest that a source upriver from GC may have contributed to exposures through drinking water, and water treatment with granular activated carbon filtration resulted in less exposure for SWO girls compared to those in NKY. PFOA has been characterized as a drinking water contaminant, and water treatment systems effective in removing PFCs will reduce body burdens.
اظهر المزيد [+] اقل [-]Temporal changes in some chlorinated hydrocarbon residue levels of Canadian breast milk and infant exposure
1994
Mes, J. (Food Research Division, Bureau of Chemical Safety, Food Directorate, Health Protection Branch, Health and Welfare Canada, Tunney's Pasture, Ottawa K1A 0L2 (Canada))
Organochlorine pesticide residues in human milk in Punjab, India
1994
Kalra, R.L. | Balwinder Singh | Battu, R.S. (Department of Entomology, Punjab Agricultural University, Ludhiana, Punjab (India))
Residues of chlorinated hydrocarbon insecticides in human milk of Jordanian women
1998
Nasir, K. | Bilto, Y.Y. | Al-Shuraiki, Y. (Department of Biological Sciences, University of Jordan, Amman (Jordan))