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Association between urinary concentration of phthalate metabolites and impaired renal function in Shanghai adults النص الكامل
2019
Chen, Jingsi | Zhou, Xiaofeng | Zhang, Han | Liu, Yueming | Cao, Chen | Dong, Ruihua | Yuan, Yaqun | Wang, Min | Lu, Yuanan | Wu, Min | Li, Shuguang | Chen, Bo
Exposure to phthalates is reported to be associated with increased incidence of microalbuminuria and low-grade albuminuria in children and adolescents. However, this phenomenon of phthalate-related nephrotoxicity is unknown in adults.Urine samples of 1663 adults from the 2012 Shanghai Food Consumption Survey (SHFCS) were measured for 10 metabolites of 6 phthalates and for renal function parameters. Their associations were explored by linear and logistic regression models.Multivariate linear regression analysis showed that all three renal function parameters (albumin-to-creatinine ratio (ACR), β2-microglobulin (B2M), and N-acetyl-β-d-glucosaminidase (NAG)) are positively associated with six metabolites, including mono-benzylphthalate (MBzP), mono-2-ethylhexylphthalate (MEHP), mono-2-ethyl-5-oxohexyphthalate (MEOHP), mono-2-ethyl-5-hydroxyhexylphthalate (MEHHP), mono-2-ethyl-5-carboxypentylphthalate (MECPP), and mono-2-carboxymethyl-hexyl phthalate (MCMHP) (P < 0.05). Logistic analysis showed that the prevalence of hyperALBuria, hyperB2Muria, hyperNAGuria, or potentially impaired renal function (PIRF) were positively associated with urinary levels of MBzP, MEOHP, and MECPP, respectively (P < 0.05). Co-exposure to identified risk metabolites monoethylphthalate (MEP), MBzP, MEHP, MEOHP, MECPP, MEHHP, and MCMHP increased the risk of having impaired renal function.Certain metabolites of phthalates, including bis (2-ethylhexyl) phthalate (DEHP) and benzyle butyl phthalate (BBzP), were associated with impaired renal function in Shanghai adults.
اظهر المزيد [+] اقل [-]Relationships between seminal plasma metals/metalloids and semen quality, sperm apoptosis and DNA integrity النص الكامل
2017
Wang, Yi-Xin | Wang, Peng | Feng, Wei | Liu, Chong | Yang, Pan | Chen, Ying-Jun | Sun, Li | Sun, Yang | Yue, Jing | Gu, Long-Jie | Zeng, Qiang | Lu, Wen-Qing
This study aimed to investigate the relationships between environmental exposure to metals/metalloids and semen quality, sperm apoptosis and DNA integrity using the metal/metalloids levels in seminal plasma as biomarkers. We determined 18 metals/metalloids in seminal plasma using an inductively coupled plasma-mass spectrometry among 746 men recruited from a reproductive medicine center. Associations of these metals/metalloids with semen quality (n = 746), sperm apoptosis (n = 331) and DNA integrity (n = 404) were evaluated using multivariate linear and logistic regression models. After accounting for multiple comparisons and confounders, seminal plasma arsenic (As) quartiles were negatively associated with progressive and total sperm motility using multivariable linear regression analysis, which were in accordance with the trends for increased odds ratios (ORs) for below-reference semen quality parameters in the logistic models. We also found inverse correlations between cadmium (Cd) quartiles and progressive and total sperm motility, whereas positive correlations between zinc (Zn) quartiles and sperm concentration, between copper (Cu) and As quartiles and the percentage of tail DNA, between As and selenium (Se) quartiles and tail extent and tail distributed moment, and between tin (Sn) categories and the percentage of necrotic spermatozoa (all Ptrend<0.05). These relationships remained after the simultaneous consideration of various elements. Our results indicate that environmental exposure to As, Cd, Cu, Se and Sn may impair male reproductive health, whereas Zn may be beneficial to sperm concentration.
اظهر المزيد [+] اقل [-]Do toxicokinetic and toxicodynamic processes hold the same for light and heavy rare earth elements in terrestrial organism Enchytraeus crypticus? النص الكامل
2020
Huang, Xueying | He, Erkai | Qiu, Hao | Zhang, Lulu | Tang, Yetao | Zhao, Chunmei | Li, Min | Xiao, Xue | Qiu, Rongliang
The widespread use of rare earth elements (REEs) in numerous sectors have resulted in their release into the environment. Existing knowledge about the effects of REEs were acquired mainly based on toxicity tests with aquatic organisms and a fixed exposure time, Here, the dynamic accumulation and toxicity of REEs (La, Ce, and Gd) in soil organism Enchytraeus crypticus were determined and modeled by a first-order one-compartment model and a time-toxicity logistic model, respectively. Generally, the accumulation and toxicity of REEs were both exposure level- and time-dependent. The overall uptake rate constants were 2.97, 2.48, and 2.38 L kg⁻¹d⁻¹ for La, Ce, and Gd, respectively. The corresponding elimination rate constants were 0.99, 0.78, and 0.56 d⁻¹, respectively. The worms exhibited faster uptake and elimination ability for light REEs (La and Ce) than for heavy REEs (Gd). For all three REEs, the LC50 values based on exposure concentrations decreased with time and reached ultimate values after approximately 10 d exposure. The estimated ultimate LC50 values (LC50∞) were 279, 334, and 358 mg L⁻¹ for Ce, Gd, and La, respectively. When expressed as body concentration, the LC50ᵢₙₜₑᵣ value was almost constant with time, demonstrating that internal body concentration could be a better indicator of dynamic toxicity of REEs than external dose. This study highlights that specific REE and exposure time should be taken into account in accurately assessing risk of REEs.
اظهر المزيد [+] اقل [-]Urbanization and cattle density are determinants in the exposure to anticoagulant rodenticides of non-target wildlife النص الكامل
2019
López-Perea, Jhon J. | Camarero, Pablo R. | Sánchez-Barbudo, Ines S. | Mateo, Rafael
The persistence and toxicity of second generation anticoagulant rodenticides (SGARs) in animal tissues make these compounds dangerous by biomagnification in predatory species. Here we studied the levels of SGARs in non-target species of wildlife and the environmental factors that influence such exposure. Liver samples of terrestrial vertebrates (n = 244) found dead between 2007 and 2016 in the region of Aragón (NE Spain) were analysed. The presence of SGARs was statistically analysed with binary or ordinal logistic models to study the effect of habitat characteristics including human population density, percentage of urban surface, livestock densities and surface of different types of crops. SGARs residues were detected in 83 (34%) of the animals and levels >200 ng/g were found in common raven (67%), red fox (50%), red kite (38%), Eurasian eagle-owl (25%), stone marten (23%), Eurasian buzzard (17%), northern marsh harrier (17%), and Eurasian badger (14%). The spatial analysis revealed that the presence of SGARs residues in wildlife was more associated with the use of these products as biocides in urban areas and cattle farms rather than as plant protection products in agricultural fields. This information permits to identify potential habitats where SGARs may pose a risk for predatory birds and mammals.
اظهر المزيد [+] اقل [-]Industrial water pollution, water environment treatment, and health risks in China النص الكامل
2016
Wang, Qing | Yang, Zhiming
The negative health effects of water pollution remain a major source of morbidity and mortality in China. The Chinese government is making great efforts to strengthen water environment treatment; however, no studies have evaluated the effects of water treatment on human health by water pollution in China. This study evaluated the association between water pollution and health outcomes, and determined the extent to which environmental regulations on water pollution may lead to health benefits. Data were extracted from the 2011 and 2013 China Health and Retirement Longitudinal Study (CHARLS). Random effects model and random effects Logit model were applied to study the relationship between health and water pollution, while a Mediator model was used to estimate the effects of environmental water treatment on health outcomes by the intensity of water pollution. Unsurprisingly, water pollution was negatively associated with health outcomes, and the common pollutants in industrial wastewater had differential impacts on health outcomes. The effects were stronger for low-income respondents. Water environment treatment led to improved health outcomes among Chinese people. Reduced water pollution mediated the associations between water environment treatment and health outcomes. The results of this study offer compelling evidence to support treatment of water pollution in China.
اظهر المزيد [+] اقل [-]A multivariate approach to analyzing functional redundancy of marine periphytic ciliates during the colonization process for bioassessment in coastal ecosystems النص الكامل
2017
Xu, Guangjian | Zhong, Xiaoxiao | Warren, Alan | Xu, Henglong
Functional redundancy is a useful tool for determining functional compensation and for reducing “signal to noise” ratios of full-species datasets in community-based monitoring programs. The functional redundancy of marine periphytic ciliate communities during the colonization process in coastal waters of the Yellow Sea, China, was analyzed using a peeling procedure (BVSTEP). Four response units (RUs) with trophic-functional equivalents were identified from the full 77-species dataset. These RUs, which comprised four, seven, six and six species respectively, represented a clear variation in trophic-functional structures across the levels of functional redundancy. RU1 was dominated by bacterivores, RU2 and RU3 first by bacterivores then by algivores, and RU4 first by non-selectives and bacterivores then by algivores. The colonization process and growth curve of each RU were significantly well-fitted to the MacArthur-Wilson and logistic models, respectively. These results suggest that RUs can be used as changeable trophic-functional equivalents for bioassessment in marine ecosystems.
اظهر المزيد [+] اقل [-]Estimation of the monetary value of biodiversity in the Central Alborz Protected Area النص الكامل
2022
Talebi Otaghvar, Yasaman | Najafi Alamdarlo, Hamed | Esmaili, Rohollah | Asadi, Mohamad Ali | Mosavi, Seyed Habibollah | Vakilpoor, Mohamad Hasan
Biodiversity refers to genetic diversity and complex sets of communities and ecosystems. Environmental degradation can jeopardize biodiversity and decrease ecosystem service quality. Biodiversity is not an endless and free commodity, and the costs of its destruction must be taken into account. Thus, estimating the monetary value of a region’s biodiversity can help stakeholders understand its economic, social, and cultural status, and ultimately, by increasing public awareness, community demands for protection and investment are properly shaped. This study aims to estimate the monetary value of biodiversity in the Central Alborz Protected Area in Iran. This area is part of the Alborz Mountain range and the wildlife and plant species of this region have a unique biodiversity. For this purpose, the willingness to pay was estimated. In designing the Choice Experiment, five attributes including “wildlife species status,” “plant species status,” “natural landscape,” “research facilities,” and “tourism facilities” have been considered. The results showed that maintaining and improving the status of animal species and tourism conditions among respondents has a higher priority than the other three attributes. The annual value of marginal willingness to pay was 13020 Tomans per person and the conservation value of biodiversity is estimated at 23 billion Tomans. Also, the results of the simple Logit model showed that the average per capita willingness to pay the respondents to protect the region is 16,369 Tomans and the value of biodiversity protection is about 28.6 billion Tomans.
اظهر المزيد [+] اقل [-]Investigating food insecurity, health and environment-related factors, and agricultural commercialization in Southwestern Nigeria: evidence from smallholder farming households النص الكامل
2022
Otekunrin, Olutosin Ademola
Hunger and food insecurity remained some of the serious challenges facing our world in present time with great concerns from Sub-Saharan Africa especially countries like Nigeria. This study investigates food insecurity (FI), health and environment-related factors, and agricultural commercialization among smallholder farm households. This study was conducted in Southwestern Nigeria utilizing cross-sectional survey data from 352 farm households and employed multi-stage sampling procedure. The household FI levels was determined using food insecurity access scale (HFIAS), crop commercialization index (CCI) was used to compute each household’s CCI (four levels), while ordered logit model was used to analyse factors influencing FI. Health and environment-related factors’ access were assessed across each FI category. The results indicated that about 13% of cassava farm households are non-participant in the marketing of their produce. The findings revealed that less than 20%, 30%. and 40% of households in all four FI categories had access to piped water, improved toilet facilities, and electricity respectively. The ordered logit regression analysis indicated that age, gender, education level, farm experience, nonfarm income, and ownership of motorcycle significantly influencing FI in the study areas. Therefore, this study stressed the implementation of policy actions capable of promoting rural infrastructure development that will lead to increased agricultural production, marketing, and improved quality of life of rural dwellers.
اظهر المزيد [+] اقل [-]Non-adoption decision of biogas in rural Pakistan: use of multinomial logit model النص الكامل
2022
Yasmin, Iram | Akram, Waqar | Adeel, Sultan | Chandio, Abbas Ali
In 2009, Pakistan introduced a subsidized biogas program to disseminate clean and affordable energy in rural areas. However, the adoption rate did not appear as expected. Therefore, the present study aims to examine the determinants behind the non-adoption of biogas digesters. Detailed information via a structured questionnaire was obtained from biogas adopters and non-adopters, and analyses were performed in two levels. Initially, the study used the multinomial logit regression to elicit the non-adoption behavior. Results depicted family size, risk aversion, cook education (women), kitchen (inside the home), home structure, and non-availability of inputs as significant factors behind non-adoption. Detailed analysis also revealed that the factors like the age of household head, area of the house, cook education (women), location of the kitchen (inside the home), and the distance of the house to the bus stop (minutes) lead towards the potential adoption of biogas. The study also investigated the potential factors behind the long-term sustainability of biogas digesters with the help of binary logit. The results depicted that the kitchen’s location (inside the house), cook education (women), training, and subsidy significantly and positively impact the biogas plant’s probability of being functional. Based on these results, the study suggested that policymakers increase women’s education in rural areas, provide a subsidy to reduce costs and risk, and arrange training for adopters.
اظهر المزيد [+] اقل [-]Arsenite removal from drinking water by bark-based magnetic iron oxide particle (BMIOP): a column study النص الكامل
2022
Dhoble, Rajesh M. | Rayalu, Sadhana | Kularkar, Ankush | Hajare, Hemant
The removal of arsenite [As(III)] from drinking water was investigated in a column at flow rates of 2.0 and 5.0 mL/min (up-flow direction) using bark-based magnetic iron oxide particles (BMIOP) prepared by coating (Fe(NO₃)₃.9H₂O) over Tamarindus Indica bark. The BMIOP was compared with regenerated BMIOP, commercial activated carbon, commercial activated alumina (Al₂O₃). At 2.0 mL/min, empty bed contact time (EBCT), breakthrough time (BT), the volume of treated water and breakthrough capacity (BC) on fresh BMIOP were found to be 6.8 min, 33.15 h, 4.380 L and 0.742 mg/g, respectively, and at 5.0 mL/min, were found to be 4.1 min, 13 h, 3.675 L and 0.453 mg/g respectively. EBCT, BT and BC were increased by 65.85%, 155% and 63.79%, respectively, as the flow rate was reduced from 5.0 to 2.0 mL/min. After regeneration of BMIOP, EBCT, BT, saturated time, BC and saturation capacity (SC) were reduced by 21.95%, 15.38%, 55.15%, 16.78% and 29.71%, respectively. The BC of fresh BMIOP was increased by factors 4.15, 3.60 and 1.20 and SC by factors 9.51, 7.88 and 1.42 compared to commercial activated carbon, commercial activated Al₂O₃ and regenerated BMIOP, respectively. Logit model could be used for the design of the adsorption column. Thomas model and artificial neural network (ANN) were applied to predict the characteristic column parameters useful for process design. Quality of treated water meets BIS requirements. Toxicity Characteristic Leaching Procedure (TCLP) and semi-dynamic tests show that the exhausted BMIOP is safe for disposal in a secure landfill; hence, BMIOP has been proved to separate As(III) from water.
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