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Effect of exposures to mixtures of lead and various metals on hypertension, pre-hypertension, and blood pressure: A cross-sectional study from the China National Human Biomonitoring
2022
Qu, Yingli | Lv, Yuebin | Ji, Saisai | Ding, Liang | Zhao, Feng | Zhu, Ying | Zhang, Wenli | Hu, Xiaojian | Lu, Yifu | Li, Yawei | Zhang, Xu | Zhang, Mingyuan | Yang, Yanwei | Li, Chengcheng | Zhang, Miao | Li, Zheng | Chen, Chen | Zheng, Lei | Gu, Heng | Zhu, Huijuan | Sun, Qi | Cai, Jiayi | Song, Shixun | Ying, Bo | Lin, Shaobin | Cao, Zhaojin | Liang, Donghai | Ji, John S. | Ryan, P Barry | Barr, Dana Boyd | Shi, Xiaoming
We aimed to explore the effects of mixtures of lead and various metals on blood pressure (BP) and the odds of pre-hypertension (systolic blood pressure (SBP) 120–139 mmHg, and/or diastolic blood pressure (DBP) 80–89 mmHg) and hypertension (SBP/DBP ≥140/90 mmHg) among Chinese adults in a cross-sectional study. This study included 11,037 adults aged 18 years or older from the 2017–2018 China National Human Biomonitoring. Average BP and 13 metals (lead, antimony, arsenic, cadmium, mercury, thallium, chromium, cobalt, molybdenum, manganese, nickel, selenium, and tin) in blood and urine were measured and lifestyle and demographic data were collected. Weighted multiple linear regressions were used to estimate associations of metals with BP in both single and multiple metal models. Weighted quantile sum (WQS) regression was performed to assess the relationship between metal mixture levels and BP. In the single metal model, after adjusting for potential confounding factors, the blood lead levels in the highest quartile were associated with the greater odds of both pre-hypertension (odds ratio (OR): 1.56, 95% CI: 1.22–1.99) and hypertension (OR:1.75, 95% CI: 1.28–2.40) when compared with the lowest quartile. We also found that blood arsenic levels were associated with increased odds of pre-hypertension (OR:1.31, 95% CI:1.00–1.74), while urinary molybdenum levels were associated with lower odds of hypertension (OR:0.68, 95% CI:0.50–0.93). No significant associations were found for the other 10 metals. WQS regression analysis showed that metal mixture levels in blood were significantly associated with higher SBP (β = 1.56, P < 0.05) and DBP (β = 1.56, P < 0.05), with the largest contributor being lead (49.9% and 66.8%, respectively). The finding suggests that exposure to mixtures of metals as measured in blood were positively associated with BP, and that lead exposure may play a critical role in hypertension development.
اظهر المزيد [+] اقل [-]Effects of e-waste exposure on biomarkers of coronary heart disease (CHD) and their associations with level of heavy metals in blood
2022
Wang, Ziye | Xue, Kaibing | Wang, Zhanshan | Zhu, Xiaojing | Guo, Chen | Qian, Yan | Li, Xiaoqian | Li, Zhigang | Wei, Yongjie
Excess heavy metals increase the risk of various diseases. Electronic waste (e-waste) is a potential route to heavy metal exposure, and Taizhou is a large e-waste dismantling area in China. In this study, we acquire blood samples from residents living near an e-waste recycling area (exposed group) and other residents in a selected reference area (reference group) for a comparative study in Taizhou in December 2017. Seven heavy metals, including cobalt (Co), nickel (Ni), cadmium (Cd), tin (Sn), copper (Cu), zinc (Zn), and lead (Pb), are quantitatively determined in all blood samples. It is discovered that the levels of Co, Ni, Sn, and Pb in the exposed group are higher than those in the reference group. Additionally, two crucial biomarkers of coronary heart disease (CHD), i.e., troponin (Tn) and myeloperoxidase (MPO), and two biomarkers of oxidative stress, i.e., malondialdehyde (MDA) and 8-isoprostane (8-I), are measured. We discovered that the levels of these indicators in the exposed group are significantly higher than those in the reference group. Meanwhile, both the Spearman correlation and multiple linear regression analysis show that Ni is positively correlated with Tn, MPO, 8-I, and MDA. Hence, we hypothesize that exposure to e-waste increases the risk of CHD and that Ni is an important contributor to the initiation of the disease.
اظهر المزيد [+] اقل [-]Association between environmental toxic metals, arsenic and polycyclic aromatic hydrocarbons and chronic obstructive pulmonary disease in the US adult population
2022
Rahman, Humairat H. | Niemann, Danielle | Munson-McGee, Stuart H.
Associations between environmental metals and chemicals and adverse human health effects have emerged recently, but the links among environmental metals and respiratory diseases are less studied. The aim of this study was to assess 14 urinary metals (cadmium, barium, cobalt, molybdenum, mercury, cesium, manganese, antimony, lead, tin, strontium, tungsten, thallium, and uranium), seven species of arsenic (arsenous acid, arsenic acid, arsenobetaine, arsenocholine, dimethylarsinic acid, monomethylarsonic acid, and total arsenic) and seven polycyclic aromatic hydrocarbon (PAH) (1-hydroxynaphthalene, 2-hydroxynaphthalene, 3-hydroxyfluorene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 1-hydroxypyrene, 2 & 3-hydroxyphenanthrene) compounds’ concentrations in urine and the correlation with chronic obstructive pulmonary disease (COPD) in the adult US population. A cross-sectional analysis using the 2013–2014 and 2015–2016 National Health and Nutrition Examination Survey (NHANES) dataset was conducted. Self-questionnaires related to COPD criteria were used to identify the COPD cases. The correlation between urinary metals and PAH compounds and COPD was calculated. The total study population analyzed included 2885 adults aged 20 years and older. Seven types of urinary PAHs including 1-hydroxynaphthalene [odds ratio (OR): 1.832, 95% confidence interval (CI): 1.210, 2.775], 2-hydroxynaphthalene [OR: 3.361, 95% CI: 1.519, 7.440], 3-hydroxyfluorene [OR: 2.641, 95% CI: 1.381, 5.053], 2-hydroxyfluorene [OR: 3.628, 95% CI: 1.754, 7.506], 1-hydroxyphenanthrene [OR: 2.864, 95% CI: 1.307, 6.277], 1-hydroxypyrene [OR: 4.949, 95% CI: 2.540, 9.643] and 2 & 3-hydroxyphenanthrene [OR: 3.487, 95% CI: 1.382, 8.795] were positively associated with COPD. Urinary cadmium [OR: 12.382, 95% CI: 4.459, 34.383] and tin [OR: 1.743, 95% CI: 1.189, 2.555] showed positive associations with increased odds of COPD. The other types of urinary metals were not associated with COPD. The study observed that urinary PAHs, cadmium, and tin are significantly associated with COPD.
اظهر المزيد [+] اقل [-]Eco-assessment of least disturbed areas of the Antalya River basin: application of diatom indices from different ecoregions
2022
Çelekli, Abuzer | Lekesiz, Ömer | Çetin, Tolga
Biomonitoring of least disturbed areas is a crucial issue to accurately assess the ecological status of surface waters and ensure their sustainability. Diatom metrics are important tools for the assessment of environmental conditions of lotic ecosystems to achieve environmental sustainability. The present study was aimed to evaluate the ecological status of least disturbed areas in the Antalya River basin (Turkey) using diatom indices developed from different ecoregion. Diatom species such as Cymbella excisa, Achnanthidium minutissimum, Cocconeis euglypta, and Cocconeis placentula were the most contributing species to the dissimilarity of sampling stations between rainy and dry seasons. The first two axes of canonical correspondence analysis (CCA) elucidated a strong (86%) correlation between diatom taxa and stressors. Results of the Monte Carlo permutation test indicated that total phosphorus (TP), water temperature, Tin (Sn), total organic carbon, zinc, and pH are significantly influential ecological factors on the distribution of diatom taxa among sampling stations. The Spearman correlation rank test indicated that diatom indices had significant positive and negative correlations with TP gradient. Results revealed that diatom indices developed from different ecoregions have different scores for the eco-assessment of similar sampling stations. European diatom indices mostly showed similar behavior in the bioassessment of the ecological status of rivers in the Antalya region compared to the different ecoregion. Among European diatom indices, TIT was more competitive and could give better results in the bio-evaluation of rivers in the Antalya River basin. Using diatom indices developed from different ecoregions may lead to an erroneous assessment of water quality. Accordingly, ecoregional specific diatom metrics are needed to accurately determine the surface water quality. Eco-assessment of least disturbed areas of the Antalya River basin: application of diatom indices from different ecoregions: Abuzer Çelekli, Ömer Lekesiz, Tolga Çetin
اظهر المزيد [+] اقل [-]Exposure to mixture of heavy metals and muscle strength in children and adolescents: a population-based study
2022
Wu, Mingyang | Shu, Yanling | Wang, Youjie
Human beings are exposed to heavy metals through various ways in daily life. However, the effect of heavy metal mixtures on muscle strength in children and adolescents remains unclear. We aimed to investigate the relationship of exposure to heavy metal mixtures (barium, cadmium, cobalt, manganese, molybdenum, lead, antimony, strontium, tin, thallium, tungsten, uranium, and cesium) with muscle strength in children and adolescents. A total of 1357 (boys, 50.8%) participants aged between 8 and 17 were extracted from the National Health and Nutrition Examination Surveys 2011–2014. Urine metals were measured by inductively coupled plasma-mass spectrometry. Muscle strength was measured through a grip test using a handgrip dynamometer. Weighted quantile sum regression was performed to estimate the mixture effect of urinary metals on muscle strength. After adjusting for potential confounders, comparing participants in the highest versus lowest quartiles of cobalt, molybdenum, lead, antimony, strontium, thallium, and cesium, the handgrip strength decreased by − 4.48 kg (95% CI: − 6.93, − 2.03), − 6.13 kg (− 8.76, − 3.51), − 2.26 kg (− 4.22, − 0.30), − 2.38 kg (− 4.68, − 0.08), − 2.29 kg (− 4.45, − 0.13), − 4.78 kg (− 7.13, − 2.44), and − 5.68 kg (− 9.20, − 2.17), respectively. Furthermore, exposure to a mixture of metals were also significantly associated with decreased muscle strength (β: − 2.62 kg; 95% CI: − 3.71, − 1.54). Findings from the present study suggest that higher heavy metal exposure and the exposure levels of a mixture of metals in urine are inversely related to handgrip strength, implying that children’s grip strength is not entirely explained by energy intake or lack of exercise, but may be related to environmental pollutants.
اظهر المزيد [+] اقل [-]Historical Record of Magnetic and Geochemical Signals in Mountain Peat Bogs: A Case Study of the Black Triangle Region (the Izery Mountains, SW Poland)
2022
Michczyński, Adam | Szuszkiewicz, Maria Magdalena | Gołuchowska, Beata | Sikorski, Jarosław
Peat bogs are effective archives of magnetic particles. The diamagnetic properties of organic matter with a zero or slightly negative value of magnetic susceptibility provide an excellent background to even small amounts of magnetic particles associated with anthropogenic activity. To the best of our knowledge, this is the first record of the technogenic magnetic particle (TMP) and potentially toxic element (PTE) contamination derived from peat archives of the study area. The investigated ombrotrophic peat bog in a historically heavily industrialized area provides an excellent starting point for future studies on the magnetic recorder and/or long-term stability properties of peatlands as archives of industrial activities. The main aim of this work was to assess the extent of overlap between the accumulation of TMPs with PTEs and iron in the peat profile and the periods of anthropogenic activity, using radiocarbon (¹⁴C) and lead (²¹⁰Pb) dating methods. In peat profiles, an enrichment in PTEs and iron was observed, corresponding to the period of maximum exploitation of lignite and lignite-based power plants in the “Black Triangle” region, as well as the exploitation of metal ores from the eighteenth century to the end of the 1990s in the twentieth century. Local influences related to the operation of the nearby glasswork and the exploitation of local tin and uranium ores were recorded in the peat layers corresponding to the time span 1774–1879 in the form of increased concentrations of As, Cu, Fe, Pb, Se, Sn, Th, Ti, U, and Zr.
اظهر المزيد [+] اقل [-]Environmental exposure to metals and the risk of high blood pressure: a cross-sectional study from NHANES 2015–2016
2022
Rahman, Humairat H | Niemann, Danielle | Munson-McGee, Stuart H.
Exposure to metal pollution can be caused from inhalation, ingestion, or absorption from air, water, or food. Chronic exposure to trace amounts of metals can lead to high blood pressure, or hypertension, and other chronic diseases. The rationale of our study was to determine if there was a correlation between nineteen forms of urinary metal concentrations and high blood pressure, defined as ≥ 130 mm Hg systolic or ≥ 80 mm Hg diastolic, in the adult US population, to understand the possible impacts of metal exposure on humans. Five types of urinary arsenic species and fourteen types of urinary metals were studied to examine their correlation with high blood pressure. We used the dataset from the 2015–2016 National Health and Nutrition Examination Survey (NHANES) for the study. A specialized complex survey design analysis package was used in analyzing the NHANES data. We used pairwise t tests and the logit regression models to study the correlation between urinary arsenic (five types) and urinary metal (fourteen types) concentrations and high blood pressure. The total study population analyzed included 4037 adults aged 20 years and older, of whom 57.9% of males and 51.7% of females had high blood pressure. Urinary arsenous acid (OR: 2.053, 95% CI: 1.045, 4.035), tin (OR: 1.983, 95% CI: 1.169, 3.364), and cesium (OR: 2.176, 95% CI: 1.013, 4.675) were associated with increased odds of high blood pressure. The other four types of urinary arsenic and twelve types of urinary metals were not associated with high blood pressure. Our results determined that exposure to environmental metals such as arsenous acid, tin, and cesium can be associated with high blood pressure. Further investigation is suggested to support our findings.
اظهر المزيد [+] اقل [-]Microplastics as vectors of metals contamination in Mediterranean Sea
2022
Squadrone, Stefania | Pederiva, Sabina | Bezzo, Tabata | Sartor, Rocco Mussat | Battuello, Marco | Nurra, Nicola | Griglione, Alessandra | Brizio, Paola | Abete, Maria Cesarina
Microplastics are contaminants of great concern all over the world. Microplastics constitute pollutants themselves; moreover, other contaminants such as metals are easily absorbed on their plastic surface, becoming bioavailable to marine biota such as zooplankton.We collected marine zooplankton from Mediterranean Sea to investigate trace elements associated with microplastics. Samples were subjected to visual sorting by a stereomicroscope, collected with sterile tweezers, pooled and subjected to sonication, filtration, and drying before being subjected to acid extraction. An ICP-MS was utilized for multi-elemental determination.Aluminum, iron, chromium, zinc, nickel, molybdenum, manganese, lead cobalt, and copper were found at concentrations of mg/kg while arsenic, vanadium, rubidium, and cadmium at level of μg kg⁻¹. Other elements such as silver, beryllium, bismuth, selenium, tin, and thallium were under the limit of quantitation. Lower levels of iron and manganese in samples from Italy were found in comparison to England and Brazil, while aluminum, copper, and zinc registered comparable values. The presence of metals in marine waters is strictly related to sediment lithology and anthropogenic inputs, but plastic plays a key role as vectors for metal ions in the marine system, being able to concentrate metals several order of magnitude higher than in surrounding waters and exerting potential toxicity for living beings after chronic exposure.
اظهر المزيد [+] اقل [-]Urinary metals, arsenic, and polycyclic aromatic hydrocarbon exposure and risk of chronic bronchitis in the US adult population
2022
Rahman, Humairat H | Niemann, Danielle | Munson-McGee, Stuart H.
Metals, arsenic, and polycyclic aromatic hydrocarbons (PAHs) have all been linked to respiratory diseases. Chronic bronchitis, which is a form of chronic obstructive pulmonary disease (COPD), is a major public health concern and source of morbidity and mortality in the US. The purpose of this study was to analyze the correlation of 14 urinary metals (antimony, barium, cadmium, cesium, cobalt, lead, manganese, mercury, molybdenum, strontium, thallium, tin, tungsten, uranium), seven species of arsenic, and seven forms of polycyclic aromatic hydrocarbon (PAH) concentrations and chronic bronchitis in the US population. A cross-sectional analysis using three datasets from the National Health and Nutrition Examination Survey (NHANES) between 2011 and 2016 in adults, aged 20 years and older. Chronic bronchitis was determined using a self-questionnaire from the NHANES dataset. A specialized weighted complex survey design analysis package was used to analyze NHANES data. Multivariate logistic regression models were used to determine the correlation between urinary metals, arsenic, PAHs, and chronic bronchitis. Models were adjusted for lifestyle and demographic factors. A total of 4186 participants were analyzed; 49.8% were female and 40.5% were non-Hispanic White. All seven types of PAHs showed a positive association with chronic bronchitis (1-hydroxynaphthalene odds ratio (OR): 1.559, 95% confidence interval (CI): 1.271–1.912; 2-hydroxynaphthalene OR: 2.498, 95% CI: 1.524–4.095; 3-hydroxyfluorene OR: 2.752, 95% CI: 2.100–3.608; 2-hydroxyfluorene OR: 3.461, 95% CI: 2.438–4.914; 1-hydroxyphenanthrene OR: 2.442, 95% CI: 1.515–3.937; 1-hydroxypyrene OR: 2.828, 95% CI: 1.728–4.629; 2 & 3-hydroxyphenanthrene OR: 3.690, 95% CI: 2.309–5.896). Of the metals, only urinary cadmium showed a statistically significant positive association (OR: 2.435, 95% CI: 1.401–4.235) with chronic bronchitis. No other metals or arsenic were correlated with chronic bronchitis. Seven forms of urinary PAHs, cadmium, and several demographic factors were associated with chronic bronchitis.
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