خيارات البحث
النتائج 791 - 800 من 4,309
In vivo assessment of dermal adhesion, penetration, and bioavailability of tetrabromobisphenol A النص الكامل
2017
Yu, Yunjiang | Li, Liangzhong | Li, Hongyan | Yu, Xiaowei | Zhang, Yanping | Wang, Qiong | Zhou, Zhixiang | Gao, Dandan | Ye, Hao | Lin, Bigui | Ma, Ruixue
Individuals are exposed to brominated flame retardants (BFRs), including tetrabromobisphenol A (TBBPA), on a daily basis because of their widespread usage. These compounds may have adverse effects on human health. In the present study, dermal absorption experiments were conducted in vivo to predict the adhesion, penetration, and bioavailability of TBBPA. TBBPA was administered to Wistar rats for 6 h by repeated dermal exposure at doses of 20, 60, 200, and 600 mg of TBBPA per kg of body weight (bw). The skin adhesion coefficient (AC) was calculated using a difference-value method and ranged from 0.12 to 3.25 mg/cm2 and 0.1 to 2.56 mg/cm2 for the male and female rats, respectively. The adhesion rate was 70.92%. According to Fick's first law of diffusion, the diffusion constant (D) was 1.4 × 10−4 cm2/h and the permeation coefficient (Kp) was 1.26 × 10−5 cm/h for TBBPA. TBBPA levels in the blood, urine, and feces of the male rats were significantly higher than those in the female rats. The dermal bioavailability of TBBPA was 24.71% for male rats and 20.05% for female rats 24 h after exposure.
اظهر المزيد [+] اقل [-]Microplastic contamination in Lake Winnipeg, Canada النص الكامل
2017
Anderson, Philip J. | Warrack, Sarah | Langen, Victoria | Challis, Jonathan K. | Hanson, Mark L. | Rennie, Michael D.
Microplastics are an emerging contaminant of concern in aquatic ecosystems. To better understand microplastic contamination in North American surface waters, we report for the first time densities of microplastics in Lake Winnipeg, the 11th largest freshwater body in the world. Samples taken 2014 to 2016 revealed similar or significantly greater microplastic densities in Lake Winnipeg compared with those reported in the Laurentian Great Lakes. Plastics in the lake were largely of secondary origin, overwhelmingly identified as fibres. We detected significantly greater densities of microplastics in the north basin compared to the south basin of the lake in 2014, but not in 2015 or 2016. Mean lake-wide densities across all years were comparable and not statistically different. Scanning electron microscopy with energy dispersive X-ray spectroscopy indicated that 23% of isolated particles on average were not plastic. While the ecological impact of microplastics on aquatic ecosystems is still largely unknown, our study contributes to the growing evidence that microplastic contamination is widespread even around sparsely-populated freshwater ecosystems, and provides a baseline for future study and risk assessments.
اظهر المزيد [+] اقل [-]Microplastics in the sediments of a UK urban lake النص الكامل
2017
Vaughan, Rebecca | Turner, Simon D. | Rose, N. L. (Neil L.)
While studies on microplastics in the marine environment show their wide-distribution, persistence and contamination of biota, the freshwater environment remains comparatively neglected. Where studies on freshwaters have been undertaken these have been on riverine systems or very large lakes. We present data on the distribution of microplastic particles in the sediments of Edgbaston Pool, a shallow eutrophic lake in central Birmingham, UK. These data provide, to our knowledge, the first assessment of microplastic concentrations in the sediments of either a small or an urban lake and the first for any lake in the UK. Maximum concentrations reached 25–30 particles per 100 g dried sediment (equivalent to low hundreds kg−1) and hence are comparable with reported river sediment studies. Fibres and films were the most common types of microplastic observed. Spatial distributions appear to be due to similar factors to other lake studies (i.e. location of inflow; prevailing wind directions; propensity for biofouling; distribution of macroplastic debris) and add to the growing burden of evidence for microplastic ubiquity in all environments.
اظهر المزيد [+] اقل [-]Double strand break repair and γ-H2AX formation in erythrocytes of medaka (Oryzias latipes) after γ-irradiation النص الكامل
2017
Sayed, Alaa El-Din Hamid | Igarashi, Kento | Watanabe-Asaka, Tomomi | Mitani, Hiroshi
The study of the DNA damage response in erythrocytes after γ-irradiation may provide evidence for its effectiveness as a biomarkers for genotoxic environmental stress. We previously reported various malformations in erythrocytes of medaka irradiated with10 Gy, but not in their micronuclei. In this study, we optimized an assay method for γ-H2AX and double strand breaks in erythrocytes of adult medaka fish after 15 Gy of γ-irradiation. The highest level of apoptosis and nuclear abnormalities, including in micronuclei, were recorded 4 h after γ-irradiation, as was the highest level of γ-H2AX foci in erythrocytes. These results suggest that recognition and repair processes occur as a response to DNA damage in erythrocytes in medaka.
اظهر المزيد [+] اقل [-]Polyfluoroalkyl substance exposure in the Mid-Ohio River Valley, 1991–2012 النص الكامل
2017
Herrick, Robert L. | Buckholz, Jeanette | Biro, Frank M. | Calafat, Antonia M. | Ye, Xiaoyun | Xie, Changchun | Pinney, Susan M.
Industrial discharges of perfluorooctanoic acid (PFOA) to the Ohio River, contaminating water systems near Parkersburg, WV, were previously associated with nearby residents' serum PFOA concentrations above US general population medians. Ohio River PFOA concentrations downstream are elevated, suggesting Mid-Ohio River Valley residents are exposed through drinking water.Quantify PFOA and 10 other per- and polyfluoroalkyl substances (PFAS) in Mid-Ohio River Valley resident sera collected between 1991 and 2013 and determine whether the Ohio River and Ohio River Aquifer are exposure sources.We measured eleven PFAS in 1608 sera from 931 participants. Serum PFOA concentration and water source associations were assessed using linear mixed-effects models. We estimated between-sample serum PFOA using one-compartment pharmacokinetics for participants with multiple samples.In serum samples collected as early as 1991, PFOA (median = 7.6 ng/mL) was detected in 99.9% of sera; 47% had concentrations greater than US population 95th percentiles. Five other PFAS were detected in greater than 82% of samples; median other PFAS concentrations were similar to the US general population. Serum PFOA was significantly associated with water source, sampling year, age at sampling, tap water consumption, pregnancy, gravidity and breastfeeding. Serum PFOA was 40–60% lower with granular activated carbon (GAC) use. Repeated measurements and pharmacokinetics suggest serum PFOA peaked 2000–2006 for participants using water without GAC treatment; where GAC was used, serum PFOA concentrations decreased from 1991 to 2012.Mid-Ohio River Valley residents appear to have PFOA, but not other PFAS, serum concentrations above US population levels. Drinking water from the Ohio River and Ohio River Aquifer, primarily contaminated by industrial discharges 209–666 km upstream, is likely the primary exposure source. GAC treatment of drinking water mitigates, but does not eliminate, PFOA exposure.
اظهر المزيد [+] اقل [-]Characterisation and source identification of the total airborne particulate matter collected in an urban area of Aracaju, Northeast, Brazil النص الكامل
2017
Almeida, Tarcísio S. | Sant´Ana, Mirna O. | Cruz, Jersica M. | Tormen, Luciano | Frescura Bascuñan, Vera Lúcia A. | Azevedo, Pericles A. | Garcia, Carlos Alexandre B. | Alves, José do Patrocínio H. | Araujo, Rennan G.O.
In this work, studies using samples collected in an urban area of Aracaju city, Sergipe State, Northeast, Brazil revealed that soil dust in suspension was the main source of total airborne particulate matter (TAPM), followed by vehicular pollution. The concentration profiles for Cu, Fe, Mn, Ni, V and Ti were established for the collected TAPM samples. The concentrations of SO2 and smoke were also measured all along the 42 sampling days. Through multivariate data analysis of the results a correlation between Fe, Mn, Ni and Ti in the mineral composition of the particles was established, indicating soil dust in suspension as the main source of TAPM. The concentrations of Cu and smoke were found to be related to vehicular traffic, and the second largest source of TAPM. Enrichment factors (EF) were calculated for the studied elements, and only Cu was found to be enriched. The concentrations of the elements in TAPM were evaluated using the geoaccumulation index (Igeo), and Fe, Mn, Ni, V and Ti were found to derive from natural sources, in TAPM. However, approximately 55% of the samples did not presented Cu contamination (Igeo≤0), and the remaining 45% presented Cu concentrations levels that indicated between low to moderate (0<Igeo≤1) and moderate to heavy contamination (2<Igeo≤3) in the urban area of Aracaju city, Sergipe State, Northeast, Brazil.
اظهر المزيد [+] اقل [-]Decreased lung function with mediation of blood parameters linked to e-waste lead and cadmium exposure in preschool children النص الكامل
2017
Zeng, Xiang | Xu, Xijin | Boezen, H Marike | Vonk, Judith M. | Wu, Weidong | Huo, Xia
Blood lead (Pb) and cadmium (Cd) levels have been associated with lower lung function in adults and smokers, but whether this also holds for children from electronic waste (e-waste) recycling areas is still unknown. To investigate the contribution of blood heavy metals and lung function levels, and the relationship among living area, the blood parameter levels, and the lung function levels, a total of 206 preschool children from Guiyu (exposed area), and Haojiang and Xiashan (reference areas) were recruited and required to undergo blood tests and lung function tests during the study period. Preschool children living in e-waste exposed areas were found to have a 1.37 μg/dL increase in blood Pb, 1.18 μg/L increase in blood Cd, and a 41.00 × 109/L increase in platelet counts, while having a 2.82 g/L decrease in hemoglobin, 92 mL decrease in FVC and 86 mL decrease in FEV1. Each unit of hemoglobin (1 g/L) decline was associated with 5 mL decrease in FVC and 4 mL decrease in FEV1. We conclude that children living in e-waste exposed area have higher levels of blood Pb, Cd and platelets, and lower levels of hemoglobin and lung function. Hemoglobin can be a good predictor for lung function levels.
اظهر المزيد [+] اقل [-]Effects of selenite on Microcystis aeruginosa: Growth, microcystin production and its relationship to toxicity under hypersalinity and copper sulfate stresses النص الكامل
2017
Zhou, Chuanqi | Huang, Jung-Chen | Liu, Fang | He, Shengbing | Zhou, Weili
Se laden freshwater algae that enter the Salton Sea with river water pose ecorisks to wildlife in the lake by transferring selenium (Se) to higher trophic levels. The aim of this study was to investigate impacts of Se on Microcystis aeruginosa, widely distributed in freshwater bodies, and its relationship with toxicity, such as microcystins and Se residues. When supplied with selenite, the 96 h-IC50 was calculated 2.60 mg Se/L. However, these inhibitory effects did not extend to microcystin production, and the extracellular fraction significantly increased with selenite as well as sulfate. As M. aeruginosa assimilated selenite very efficiently, 97% of the removed Se was through accumulation, compared to 3% via volatilization, raising a concern about ecotoxicity caused by the remaining Se in the algae. The XAS analysis suggests the dominant Se species accumulated in the algal cells was elemental Se (81%), which is relatively nonbioavailable to aquatic organisms. We further investigated the potential fate of Se carried into the Salton Sea by M. aeruginosa with river water. Under hypersalinity stress, the biomass Se and intracellular microcystins were released and reduced by 47% and 74%, respectively, resulting in the increasing levels of Se and microcystins in the water column. CuSO4 was then applied as an algaecide to prevent M. aeruginosa from entering the lake. The results indicate a similar response to that under hypersalinity stress: the volatilization process was blocked and the Se and microcystins were released from the damaged algal cells in the presence of CuSO4, further raising toxicity levels by 8% and 60%, respectively, in the water column within 24 h. Overall, the coexistence of selenite and M. aeruginosa in river waters might negatively impact aquatic ecosystems of the Salton Sea and further research is required on how to harvest Se from M. aeruginosa to protect local wildlife.
اظهر المزيد [+] اقل [-]Attributable risks of emergency hospital visits due to air pollutants in China: A multi-city study النص الكامل
2017
Chen, Gongbo | Zhang, Yongming | Zhang, Wenyi | Li, Shanshan | Williams, Gail | Marks, Guy B. | Jalaludin, Bin | Abramson, Michael J. | Luo, Fengming | Yang, Dong | Su, Xin | Lin, Qichang | Liu, Laiyu | Lin, Jiangtao | Guo, Yuming
Air pollution is associated with risks of mortality in China, but the evidence is still limited for morbidity. This study aims to examine overall effects of ambient air pollutants on emergency hospital visits (EHVs) at the national level in China and calculate corresponding attributable risks. We collected daily data for EHVs from 33 largest hospitals in China between Oct 2013 and Dec 2014, as well as daily measurements of particulate matter (PM10 and PM2.5: particles with aerodynamic diameter < 10 μm and 2.5 μm, respectively), nitrogen dioxide (NO2) and sulphur dioxide (SO2) from 31 cities where the hospitals were located. Firstly, quasi-Poisson regression with a constrained distributed lag model (CDLM) was employed to examine city-specific associations of EHVs with each pollutant. Then, the effects at the national scale were pooled with a random-effect meta-analysis. Daily EHVs was significantly associated with a 10 μg/m3 increase in PM2.5 at lag 0–2 days [cumulative relative risk (RR) and 95% confidence intervals (CI): 1.006 (1.002, 1.009)], PM10 at lag 0–1 days [1.004 (1.002, 1.006)], NO2 at lag 0–1 days [1.015 (1.010, 1.019)] and SO2 at lag 0–2 days [1.022 (1.014, 1.030)]. The effect estimates were not modified by sex, but stronger effects were observed among children than adults. Overall, 3.34% of EHVs may result from exposure to ambient PM2.5, 3.96% to PM10, 5.90% to NO2 and 5.38% to SO2. Exposure to outdoor air pollution has acute effects on EHVs. Effective measures to control air pollution levels in China could potentially reduce demands for emergency hospital services.
اظهر المزيد [+] اقل [-]Testing the time-scale dependence of delayed interactions: A heat wave during the egg stage shapes how a pesticide interacts with a successive heat wave in the larval stage النص الكامل
2017
Janssens, Lizanne | Tüzün, Nedim | Stoks, Robby
Under global change organisms are exposed to multiple, potentially interacting stressors. Especially interactions between successive stressors are poorly understood and recently suggested to depend on their timing of exposure. We particularly need studies assessing the impact of exposure to relevant stressors at various life stages and how these interact. We investigated the single and combined impacts of a heat wave (mild [25 °C] and extreme [30 °C]) during the egg stage, followed by successive exposure to esfenvalerate (ESF) and a heat wave during the larval stage in damselflies. Each stressor caused mortality. The egg heat wave and larval ESF exposure had delayed effects on survival, growth and lipid peroxidation (MDA). This resulted in deviations from the prediction that stressors separated by a long time interval would not interact: the egg heat wave modulated the interaction between the stressors in the larval stage. Firstly, ESF caused delayed mortality only in larvae that had been exposed to the extreme egg heat wave and this strongly depended upon the larval heat wave treatment. Secondly, ESF only increased MDA in larvae not exposed to the egg heat wave. We found little support for the prediction that when there is limited time between stressors, synergistic interactions should occur. The intermediate ESF concentration only caused delayed mortality when combined with the larval heat wave, and the lowest ESF concentrations only increased oxidative damage when followed by the mild larval heat wave. Survival selection mitigated the interaction patterns between successive stressors that are individually lethal, and therefore should be included in a predictive framework for the time-scale dependence of the outcome of multistressor studies with pollutants. The egg heat wave shaping the interaction pattern between successive pesticide exposure and a larval heat wave highlights the connectivity between the concepts of ‘heat-induced pesticide sensitivity’ and ‘pesticide-induced heat sensitivity’.
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