Various industrial processes with a huge variety of products, materials and compounds create different kinds of pollution for human beings, so that the identification of environmental pollutants resulting from industrial units’ activities, especially in water resources seems necessary. The aim of this paper is to estimate the role of industrial units in contaminating water resources, through using pollution index in the effective area on Sabzevar water resources and ranking them according to their level of contamination. The research method in this paper is descriptive-analytical, and the research data is collected using methods of field data collection. In this study, because of the abundant existence of nitrogen pollutants in water resources in the region we tried to use the burden of nitrogen emission to estimate the volume of industrial pollution. The findings showed that pollution brunt resulting from industrial units of the area on nitrogen in 2008 is equal to twenty three tones, in which leather production units, with approximately forty five percent had the greatest role. According to the findings, waste separation plan of industrial wastewater from municipal as well as establishment of refinery networks which operate wastewater collection and treatment separately in industrial units in the range of Sabzevar, industrial zones and other industries in the studied area has been proposed