Air pollution is one of the most important problems of industrial cities. The existence of large industrial factories, official and industrial facilities, National Iranian South Oil Company, National Iranian Drilling Company, etc., have turned Ahvaz to one of the main industrial centers and one of the most polluted cities of Iran. Coming into contact with airborne microorganisms is related to a host of negative effects on the human health. This study was carried out to find out the effect of oil industries on air pollution and its optimal locating through the environmental approach in Ahvaz metropolis. In this study, SCREEN3 software was used to find out and analyze the distribution of Sox, NOx, and CO pollutants. Based on expert opinion, the main criteria were determined as climatic, natural, environmental, and economic factors. After calculating weights through the AHP model and attaining the information layers, the GIS software capabilities to combine and overlap the maps were used. This led to a map depicting the optimal location of oil industries congruent with the environmental approach in Ahvaz metropolis. According to the obtained results, there should be no residence-based activity in at least 5000 meters distance from the oil industries, where air pollutants have a considerable density. That is to say, within this distance, the animate and inanimate creatures will be damaged the most. The most optimal areas for the establishment of oil industry facilities are located on the west, south, southwest, and parts of east and north of the area under study.