Processing of melon plays a significant role in the livelihood of rural women as it serves as their major occupation. Despite its significant role, the women processors were faced with some challenges. This study, therefore, identified the challenges faced by women in melon processing in Enugu-Ezike Agricultural Zone of Enugu State, Nigeria. Primary data were collected from 80 respondents using a structured questionnaire coupled with an interview schedule and analysed using descriptive statistics. The results showed that the majority of the women processors were advanced in age, well experienced, do not belong to a cooperative society, and relied strictly on processing melon as their source of livelihood. They had an average income of N286,400 (USD 751.71) per annum. Low capital, poor credit facilities, high transportation cost, price fluctuation, rapid deterioration, low supply of melon, poor storage facilities, high cost of processing machine, and breakage of seed were the identified constraints facing them. The study recommended that the women processors should form a cooperative society which will help in financing and easy marketing of their products. Also, the government should provide financial assistance, good storage facilities, and subsidized melon processing machine to increase efficiency.