A study was carried out to assess the culture performance of monosex and mixed-sex tilapia (Oreochromis niloticus) in underground brackish water by using semi-intensive integrated pond system. The experiment was conducted in three earthen ponds for a period of 11 months. In pond-1 (P1), 200 females and in pond-2 (P2), 200 males, while in pond-3 (P3), 100 male and 100 female tilapias were stocked. Salt-tolerant fresh biomass, i.e. Leptochloa fusca (Kallar grass), Brachiaria mutica (Para grass) and Kochia indica (Kochia) was used as supplemental feed. Fertilization of all ponds was done with goat droppings @ 6000 kg per ha and nitrophos @ 7.5 kg per ha. Results indicated that tilapia was found well adapted to the saline environment. The net fish production was calculated as 1295, 1752 and 914 kg per ha per year in female, male and mixed tilapia ponds, respectively. Male tilapia culture resulted in a significant (P less than 0.05) increase in fish production.