Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities
Bing-Chao Yan; Wei-Guang Wang; Ling-Mei Kong; Jian-Wei Tang; Xue Du; Yan Li; Pema-Tenzin Puno
Cytochalasans from the endophytic fungi featured structure diversity. Our previous study has disclosed that cytochalasans from the endophytic fungus Phomopsis sp. shj2 exhibited an antimigratory effect. Further chemical investigation on Phomopsis sp. shj2 has led to the discovery of seven new cytochalasans (1&ndash:7), together with four known ones. Their structures were elucidated through extensive spectroscopic data interpretation and single-crystal X-ray diffraction analysis. Compounds 1&ndash:3 and 8&ndash:11 exhibited antimigratory effects against MDA-MB-231 in vitro with IC50 values in the range of 1.01&minus:10.42 &mu:M.
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