An Eco-Friendly Technique: Solvent-Free Microwave Synthesis and Docking Studies of Some New Pyridine Nucleosides and Their Pharmacological Significance
2019
Majed Alrobaian | Sana Al Azwari | Amany Belal | Hany A. Eldeab
Two series of novel 5-arylazo-3-cyano-2-(2&Prime:,3&Prime:,4&Prime:,6&Prime:-tetra-O-acetyl-&beta:-d-galacto pyranosyloxy) pyridines and 3-cyano-2-(2&Prime:,3&Prime:,4&Prime:,6&Prime:-tetra-O-acetyl-&beta:-d-galactopyranosyloxy) pyridines were synthesized in high yields utilizing a microwave-assisted synthesis tool guided by the principles of green chemistry. The chemical structures of the new substances were confirmed on the basis of their elemental analysis and spectroscopic data (FT-IR, 1D, 2D-NMR). Activity against different bacterial strains was studied. The anticancer potential of the new compounds is also discussed. Molecular docking was used as a tool in this research work to get better insight into the possible interactions, affinities, and expected modes of binding of the most promising derivatives of the potential chemotherapeutic target (DHFR).
Show more [+] Less [-]Bibliographic information
This bibliographic record has been provided by Multidisciplinary Digital Publishing Institute