One-Step Regioselective Synthesis of Benzofurans from Phenols and α-Haloketones
2019
Bingqiao Wang | Qiu Zhang | Juan Luo | Zongjie Gan | Wengao Jiang | Qiang Tang
Reported here is the direct synthesis of naphthofurans and benzofurans from readily available phenols and &alpha:-haloketones promoted by titanium tetrachloride which combines Friedel&ndash:Crafts-like alkylation and intramolecular cyclodehydration into one step. This simple protocol allows for the formation of a variety of high value naphthofurans and benzofurans within which a series of cyclic and acyclic groups are readily incorporated. This process demonstrates the advantages of high levels of regioselectivity, broad substrate scope, and moderate to excellent yields.
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