The Five-Year Prospective Study of Quality of Life in Hemifacial Spasm Treated with Abo-Botulinum Toxin A
2021
Subsai Kongsaengdao | Narong Maneeton | Benchalak Maneeton
This study aimed to determine the long-term quality of life (QoL) in hemifacial spasm (HFS) patients after treating with Abo-botulinum toxin A (Abo-BTX). The study assessed the disease-specific QoL (hemifacial spasm questionnaire 30 items: HFS 30), the involuntary movements (abnormal involuntary movement scale: AIMS), general health QoL (Medical Outcomes 36-Item Short Form Health Survey: SF-36), and Depression (the Center of Epidemiologic Studies-Depression questionnaire: CES-D). A total of 74 HFS patients were enrolled from 2012 to 2017. The disease-specific QoL: involuntary movements: and the general health domain of SF 36 were significantly improved after injections of Abo-BTX A in the first few years (p <: 0.04), but significantly decreased at the fifth year of treatment without significant clinical resistance observed (p <: 0.001). Only the general health domain of SF 36 showed persistent improvement over five years (p = 0.02). In summary, Abo-BTX A can improved quality of life in the first few years: however only the general health domain of SF-36 showed significant improvement over five years (p = 0.02). No clinical resistance was observed.
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