Spiralyde A, an Antikinetoplastid Dolabellane from the Brown Alga Dictyota spiralis
2019
Olfa Chiboub | Ines Sifaoui | Jacob Lorenzo-Morales | Manef Abderrabba | Mondher Mejri | José Javier Fernández | José E. Piñero | Ana R. Díaz-Marrero
Bioassay-guided fractionation of the antikinetoplastid extract of the brown alga Dictyota spiralis has led to the isolation of spiralyde A (1), a new dolabellane aldehyde, along with other five known related diterpenes (2&ndash:6). Their structures were determined by HRESIMS, 1D and 2D NMR spectroscopy, and comparison with data reported in the literature. The antiparasitic activity of all compounds was evaluated. Spiralyde A (1) and the known compound 3,4-epoxy-7,18-dolabelladiene (2) were the most active compounds against Leishmania amazonensis and Trypanosoma cruzi. Spiralyde A (1) was the most potent compound, comparable to benznidazole, the reference drug for trypanocidal activity.
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