HAPTENIC PROPERTIES OF PARALYTIC SHELLFISH POISON
2006
Campbell, J. E.
Research conducted for the U.S. Army Biological Labs., Ft. Detrick, MD.
Show more [+] Less [-]Injection of paralytic shellfish poison (PSP) conjugated to formalin- treated bovine serum albumin (PSP-HCHO-BSA) into rabbits resulted in the production of sera capable of precipitating with their homologous antigen as well as with formalin treated heterologous protein. Anti-PSPHCHO-BSA sera of high titer and strong reactivity were capable of protecting white mice from the lethal action of PSP when injected I.P. with serum and later challenged by the same route. Passive immunity was not conferred to mice which received sera that showed little or no ability to precipitate PSP-HCHO-BSA. Evidence is presented to indicate that PSP does not exist in a stable protein conjugate in frozen Gonyaulaux catenella cells.
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