Gene-Environment Interaction and Breast Cancer on Long Island, NY
2006
Teitelbaum, Susan
This research project will build upon the Long Island Breast Cancer Study Project (LIBCSP), a large population-based, case-control study of the environment and breast cancer. Participants completed an in-person interviewer-administered interview, donated blood and urine samples, and had home environment samples (dust, soil, and water) collected. For this study, 200 cases and 200 controls who donated urine samples will be selected and their urine samples will be analyzed for a panel of environmental estrogen (EE) biomarkers. In addition, these same women will be screened for polymorphisms in both the estrogen receptor alpha and beta genes. Breast cancer risk in relation to the combination of these multiple EE exposures and gene-environment interactions will be investigated using sophisticated statistical methods, such as hierarchical regression models and factor analysis. Additionally, a pilot investigation of the correlation between EE levels in house dust and urinary biomarker levels will be conducted. Currently, samples for this study have been selected and the laboratory analyses are underway. Results of the proposed research project will be of enormous public health relevance since they may advance researchers' knowledge of modifiable breast cancer risk factors and newly identified EEs, thereby providing information that is essential for primary prevention.
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