Aurantoside J: a New Tetramic Acid Glycoside from Theonella swinhoei. Insights into the Antifungal Potential of Aurantosides
2011
Rihab F. Angawi | Giorgio Bavestrello | Barbara Calcinai | Henny Adeleida Dien | Giovanna Donnarumma | Maria Antonietta Tufano | Iole Paoletti | Elena Grimaldi | Giuseppina Chianese | Ernesto Fattorusso | Orazio Taglialatela-Scafati
The chemical investigation of an Indonesian specimen of Theonella swinhoei afforded four aurantosides, one of which, aurantoside J (5), is a new compound. The structure of this metabolite, exhibiting the unprecedented N-α-glycosidic linkage between the pentose and the tetramate units, has been determined through detailed spectroscopic analysis. The four obtained aurantosides have been tested against five fungal strains (four Candida and one Fusarium) responsible of invasive infections in immuno-compromised patients. The non-cytotoxic aurantoside I (4) was the single compound to show an excellent potency against all the tested strains, thus providing valuable insights about the antifungal potential of this class of compounds and the structure-activity relationships.
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