Enantiomeric discorhabdin alkaloids and establishment of their absolute configurations using theoretical calculations of electronic circular dichroism spectra

Grkovic, T; Ding, YQ; Li, XC; Webb, VL; Ferreira, D; Copp, BR

Enantiomeric discorhabdin alkaloids and establishment of their absolute configurations using theoretical calculations of electronic circular dichroism spectra

2008

Enantiomeric pairs of the cytotoxic pyrroloiminoquinone marine alkaloids discorhabdins B (2), G*/I (3), L (4), and W (5) have been isolated from Latrunculia species sponges collected at different locations around the coast of New Zealand. The absolute configuration of all compounds was secured by comparison of observed data with the results of time-dependent density functional theory (TDDFT) calculations of electronic circular dichroism (ECD) spectra. Enantiomeric discorhabdins exhibit equipotent antiproliferative biological activity.

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AGROVOC Keywords

metabolites

Bibliographic information

Publisher

AMER CHEMICAL SOC

Other Subjects

Okinawan marine sponge; Pyrroloiminoquinone; Genus latrunculia; Optical-rotation

Language

English

License

J ORG CHEMItems in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0022-3263/https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htmCopyright: AMER CHEMICAL SOChttp://purl.org/eprint/accessRights/RestrictedAccess

ISSN

9133-9136, 0022-3263

Type

Journal Article

Source

In AGRIS since: 2013-06-15

Format: AGRIS AP

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