海洋细菌活性物质研究进展 Advances in the Bio-Active Products from Marine Bacteria—A Review
2012
徐佰亮 | 王莲芸
海洋多变复杂的环境导致了海洋微生物的多样性。近几年的研究报道显示，占海洋微生物主导地位的海洋细菌产生的活性物质种类最为丰富，因此从海洋细菌中寻找新颖独特的具有药用价值的活性物质具有巨大潜力，海洋细菌也将成为新药筛选的重要资源，在药品开发中具有良好的发展前景。本文通过对近几年在海洋细菌活性物质研究这一领域研究论文的检索和归纳，对海洋细菌活性物质的主要特点和其在抑菌、抗肿瘤和酶及酶抑制剂、抗炎等多个方面的活性进行综述，揭示了海洋细菌活性物质在药物开发中的应用现状，总结了在这一领域现阶段所存在的问题，并对其未来的发展给予了展望。<br>Ever-changing ocean environment has bred the extreme diversity of marine microorganisms. Recent re- searches showed that marine bacteria, the majority of the marine microorganism, generate abundant bio-active materials, indicating a foreseeable and great potential of the search for novel bio-active products from marine bacteria. This pro- gress has attracted attentions of both academia and business. Marine bacteria could become a new resource in drug screening and show a promising development prospect. Based on the recent works of bio-active material from marine bacteria, we reviewed their main features and active roles in the study of antibiotics, anti-tumor agents, enzyme and enzyme inhibitors, anti-inflammatory medicine and so on, revealing the current status of marine bacteria bio-active ma- terial in drug development. We summed up the problems encountered at this stage and made a prediction of probable hot spot in the future development.
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