Neuroendocrine mechanism mediating fasting stress induced suppression of luteinizing hormone secretion in female rats
1998
Estacio, M.A.C. (Philippines Univ. Los Banos, College, Laguna (Philippines). Dept. of Basic Veterinary Sciences)
The fasting-induced suppression of luteinizing hormone (LH) secretion is totally dependent on steroidal milieu because the suppression is only observed in intact or ovariectomized estrogen-primed rats but not in ovariectomized rats. The following neural pathway has been suggested by a series of experiment: A signal emanating from the stomach reaches the medulla oblongata via the afferent vagal nerves so as to activate the noradrenergic neurons projecting to the hypothalamic paraventricular nucleus (PVN); this results in an increased release of corticotropin-releasing hormone thereby suppressing LH-releasing hormone and then LH release. The PVN and A2 region of nucleus of the solitary tract are the estrogen feedback sites to activate the above mentioned neural pathway. The estrogen feedback action on the PVN and A2 region is considered to be due to an increased expression of estrogen receptors in these nuclei after 48-h fasting which is regulated by the vagus nerve inputs
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