Systems biology approach for the exploitation of Spirulina (Cyanobacteria)
2006
Cheevadhanarak, S. | Hongsthong, A. | Subudhi, S. | Sirijuntarat, M. | Dulsawat, S. | Chetkul, W. | Paithoonrangsarid, K. | Meechai, A. | Prommeenate, P. | Bhumiratana, S. | Bunnag, B. | Tanticharoen, M., King Mongkut's Univ. of Technology Thonburi, Bangkok 10140 (Thailand)
Recent advances in sequencing technologies have led to a remarkable number of sequenced cyanobacterial genomes. Analysis of these genomes along with others has provided beneficial information and knowledge to the applications of these organisms in biotechnology, agriculture, medicine, energy, and environmental technology. As Spirula is the only cyanobacterium that can be cultivated outdoor on a commercial scale, it is attractive to exploit this organism as a cell factory for the production of economically high value compounds. Towards this potential, research and development was conducted on Spirula genome sequencing, proteomics, metabolomics, and employed systems biology to formulate in silico Spirulina genome-scale model. The insight understanding into the biological processes and availability of these genetic systems of Spirulina will promote the utilization of this cyanobacterium and enable the construction of Spirulina with improved metabolic properties for various industrial purposes.
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