Does Exercise Affect Mitochondrial Function and Insulin Sensitivity?
2017
Aslı DEVRİM | Pelin BİLGİÇ
Skeletal muscle has an important role in the pathogenesis of insulin resistance. Several studies have found thatinsulin action may be related to the oxidative capacity of skeletal muscle. Aerobic exercises improve both insulinsensitivity and activity of oxidative enzymes in muscle. Individuals with insulin resistance, obesity or type 2diabetes were found to have lower muscle oxidative enzyme activity. There are some hypotheses claiming thatinsulin infusion stimulates the mitochondrial protein synthesis rate in skeletal muscle. The effects of exercise onmitochondrial dysfunction and insulin sensitivity are summarized and discussed in this review.
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