Investigation of Chemical Composition, Antioxidant, Anticholinesterase and Anti-urease activities of Euphorbia helioscopia
2018
Ebru Deveci | Gülsen Tel-Çayan | Mehmet Emin Duru
In thisstudy, chemical composition, antioxidant, anticholinesterase and anti-urease activitiesof the essential oil, hexane, acetone, methanol and water extracts of Euphorbia helioscopia were investigated.The chemical composition of the essential oil was analyzed by GC and GC/MS and β-cubebene (19.3 %), palmitic acid (12.2%) and caryophyllene oxide (11.7 %) were identified as major compounds. The antioxidantactivity of essential oil and extracts was performed by several methods such asβ-carotene-linoleic acid, DPPH•, ABTS•+ radical scavenging,CUPRAC and metal chelating assays. The water extract showed higher antioxidant activitythan BHA and α-tocopherol in β-carotene-linoleic acid, DPPH•, ABTS•+and CUPRAC assays with IC50: 1.08±0.39, 15.57±0.48, 1.89±0.33 and 12.50±0.11μg/mL values, respectively. Also, the anticholinesterase and anti-urease activitieswere tested against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) andurease enzymes, spectrophotometrically. The acetone extract (81.23±0.58 %) showedvery close BChE inhibitory activity to galantamine. The hexane extract (96.97±0.36%) of E. helioscopia showed higher anti-ureaseactivity than thiourea (96.93±0.17 %) whereas the essential oil (91.37±0.26 %) indicatedvery close anti-urease activity to the standard.
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by Directory of Open Access Journals
