Pregnane-Type Steroids from the Formosan Soft Coral Scleronephthya flexilis
2014
Chao-Ying Kuo | Yung-Shun Juan | Mei-Chin Lu | Michael Yen-Nan Chiang | Chang-Feng Dai | Yang-Chang Wu | Ping-Jyun Sung
Three pregnane-type steroids, including a new metabolite, 3β-methoxy-5,20-pregnadiene (1) along with two known analogues, 3β-acetoxy-5,20-pregnadiene (2) and 5α-pregna-1,20-dien-3-one (3) were isolated from the soft coral Scleronephthya flexilis. Standard spectroscopic techniques were used to determine the structure of new steroid 1. The absolute stereochemistry of steroid 2 was confirmed by X-ray diffraction analysis. Steroid 3 exhibited potent activity against MOLT-4 tumor cells.
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