Evolution game: which came first, the receptor or the ligand?
2007
M Mandrioli | D Malagoli | E Ottaviani
On the basis of a bioinformatic approach, we suggest that in invertebrates many ligands interact with a single, ancestral and generalized receptor driving ligand evolution. In vertebrates, on the other hand, the occurrence of gene/genome duplications induced the shift to a ligand-directed evolution of receptors.
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