Generation of human induced pluripotent stem cell line from Alzheimer’s disease patient with PSEN2 N141I mutation using integration-free non-viral method
2020
Harry Murti | Kelvin Pieknell | Indra Bachtiar | Yanuar Alan Sulistio | Sang-Hun Lee
Induced pluripotent stem cell (iPSC) line HUi001-A was reprogrammed from skin fibroblasts via non-integrating, virus free self-replicating RNA. Skin fibroblasts from an 81-year-old female Caucasian familial Alzheimer’s disease patient of Volga German family carrying N141I mutation in the PSEN2 gene (familial AD4, clinical summary confirmed Alzheimer’s disease) was obtained from the Coriell Institute (AG09908). Generated iPSCs were characterized and pluripotency was confirmed.
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