Microcirculation and pathomorphological changes in development of an experimental acute pancreatitis in rats
2008
Beregovenko I.M. | Zinenko D.Yu.
The purpose of research was definition of early microcirculation and hystosrtructure changes in a tissue of a pancreas in different models of an experimental sharp pancreatitis at rats. Used various variants of 2 models: 1) model with in-traperitoneal introduction L-arginin in dozes 3; 4 and 5 g/kg; 2) model with introduction 50 mkl 1 %-s', 2,5 %-s' and 5 %-s' solutions of sodium taurocholat in a channel of a pancreas. Hystologic research and definition of an amylases level in the blood carried out in 1, 4, 8, 12, 24, 48 and 72 hours after an injection. The lead researches on models with intraperitoneal introduction L-arginin and intrachannel introduction of sodium taurocholat have revealed a similar orientation in develop-ment of a sharp pancreatitis on dynamics of an amylases level in the blood and on pathomorphological changes of the paren-chyma, stroma and microcirculation in the body. For model with introduction of sodium taurocholat in a channel of a pan-creas are more characteristic gemorragycal displays alongside with inflammatory and necrotic changes which have an essen-tial gradient from the head to a tail of the gland. It is observed regenerative dynamics of amylase’s concentration in the blood condition, of microvessels and the general tissue structure of a pancreas of comparison with L-аrginin after application of sodium taurocholat.
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