TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia
2021
Maren Hülsemann | Colline Sanchez | Polina V. Verkhusha | Vera Des Marais | Serena P. H. Mao | Sara K. Donnelly | Jeffrey E. Segall | Louis Hodgson
Hülsemann et al. examine the role of TC10, a p21 small GTPase, in breast cancer invasion and metastasis, by regulating membrane type-1 matrix metalloproteinase (MT1- MMP) at invadopodia. The authors also develop a FRET biosensor for TC10, which is used to further investigate p190RhoGAP-dependent regulation of spatiotemporal TC10 activity.
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