Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing
2021
Shimpei I. Kubota | Kei Takahashi | Tomoyuki Mano | Katsuhiko Matsumoto | Takahiro Katsumata | Shoi Shi | Kazuki Tainaka | Hiroki R. Ueda | Shogo Ehata | Kohei Miyazono
Shimpei Kubota et al. describe a pipeline for quantitative whole-organ analysis that that combines tissue clearing, 3D imaging, and machine learning for analysis of the tumour microenvironment. The authors apply this in a mouse model of lung tumour and reveal the role of TGF-β in remodelling the cellular microenvironment favouring metastatic invasion.
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