A knockout cell library of GPI biosynthetic genes for functional studies of GPI-anchored proteins
2021
Si-Si Liu | Yi-Shi Liu | Xin-Yu Guo | Yoshiko Murakami | Ganglong Yang | Xiao-Dong Gao | Taroh Kinoshita | Morihisa Fujita
Liu et al. construct a knock out cell library of genes involved in the biosynthesis of glycosylphosphatidylinositol (GPI)-anchored protein (GPI-APs) from HEK-293 cells and analyzed the surface expression and sensitivity to phosphatidylinositol-specific phospholipase C. Furthermore, the authors also identify structural motifs of GPIs that are recognized by a GPI-binding toxin, aerolysin.
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