Mitochondrial Lon protease is a gatekeeper for proteins newly imported into the matrix
2021
Yuichi Matsushima | Kazuya Takahashi | Song Yue | Yuki Fujiyoshi | Hideaki Yoshioka | Masamune Aihara | Daiki Setoyama | Takeshi Uchiumi | Satoshi Fukuchi | Dongchon Kang
Yuichi Matsushima et al. revealed that Human ATP-dependent Lon protease (LONP1), a mitochondrial protease with unfolding activity, serves as a gatekeeper for several mitochondrial matrix entering proteins: supporting the folding of required proteins and degrading the aberrant ones.
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