The structure of a dimeric form of SARS-CoV-2 polymerase
2021
Florian A. Jochheim | Dimitry Tegunov | Hauke S. Hillen | Jana Schmitzová | Goran Kokic | Christian Dienemann | Patrick Cramer
Jochheim et al report an alternative, dimeric form of the coronavirus SARS-CoV-2 RNA dependent RNA polymerase (RdRp), which is used to replicate and transcribe its genome. They resolve its structure at 5.5 Å resolution and speculate that the dimer facilitates template switching during production of sub-genomic RNAs.
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