Malfunctioning CD106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion
2021
Miwako Katagi | Tomoya Terashima | Natsuko Ohashi | Yuki Nakae | Akane Yamada | Takahiko Nakagawa | Itsuko Miyazawa | Hiroshi Maegawa | Junko Okano | Yoshihisa Suzuki | Kazunori Fujino | Yutaka Eguchi | Hideto Kojima
Katagi et al. show that abnormal bone marrow-derived cells originated from hematopoietic stem cells (CD106-positive short-term HSCs) aberrantly fuse with neurons to develop diabetic neuropathy. This study suggests that the pathological abnormality is memorized in the bone marrow and that it cannot be erased by conventional therapy.
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