Dietary Lycopene Supplementation Could Alleviate Aflatoxin B<sub>1</sub> Induced Intestinal Damage through Improving Immune Function and Anti-Oxidant Capacity in Broilers
2021
Md Touhiduzzaman Sarker | Xiaoli Wan | Haiming Yang | Zhiyue Wang
The present study aims to evaluate the effects of lycopene (LYC) supplementation on the intestinal immune function, barrier function, and antioxidant capacity of broilers fed with aflatoxinB1 (AFB<sub>1</sub>) contaminated diet. A total of 144 one-day-old male Arbor Acres broilers were randomly divided into three dietary treatment groups; each group consisted of six replicates (eight birds in each cage). Treatments were: (1) a basal diet containing neither AFB<sub>1</sub> nor LYC (Control), (2) basal diet containing 100 µg/kg AFB<sub>1</sub>, and (3) basal diets with 100 µg/kg AFB<sub>1</sub> and 200 mg/kg LYC (AFB<sub>1</sub> and LYC). The results showed that dietary LYC supplementation ameliorated the AFB<sub>1</sub> induced broiler intestinal changes by decreasing the inflammatory cytokines interferon-γ (IFN-γ), interleukin 1beta (IL-1β), and increasing mRNA abundances of cludin-1 (CLDN-1) and zonula occludens-1 (ZO-1) in the jejunum mucosa. On the other hand, AFB<sub>1</sub>-induced increases in serum diamine oxidase (DAO) activities, D-lactate concentration, mucosal malondialdehyde (MDA), and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) concentrations were reversed by dietary LYC supplementation (p < 0.05). Additionally, LYC supplementation ameliorated the redox balance through increasing the antioxidant enzyme activities and their related mRNA expression abundances compared to AFB<sub>1</sub> exposed broilers. In conclusion, dietary supplementation with LYC could alleviate AFB<sub>1</sub> induced broiler intestinal immune function and barrier function damage and improve antioxidants status.
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