PHARMACOKINETICS OF CEFTRIAXONE FOLLOWING INTRAMUSCULAR ADMINISTRATION IN LOCAL PIG OF MIZORUM, INDIA
2016
Lalrin Puia | C. Lalmuanthanga
The pharmacokinetics of ceftriaxone was studied after intramuscular administration@ 20 mg/kg in adult Mizo local pig (zovawk). The drug concentration in plasma was quantified throughHigh Performance Liquid Chromatography (HPLC) with UV detector. The maximum plasmaconcentrations (Cmax) of 25.92±1.05 µg.ml-1wasachieved at 0.5 h (Tmax), while the lowest plasmaceftriaxone concentration of 0.22±0.04 µg.ml-1wasobserved at 24 hfollowing intramuscularadministration of ceftriaxone. It has been observed that plasma concentrations of ceftriaxone wasmaintained up to 24 h (1440 min) during the present investigation following IM administration ofceftriaxone @ 20 mg.kg-1 body weight. Pharmacokinetic profile and excellent bioavailability ofceftriaxone indicated that the drug can be used intramuscularly to treat susceptible bacterial infectionsin pig.
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