Symposium 13: Prediabetes and brain
2022
Gustavo Díaz
Prediabetes is a serious but reversible problem characterized by hyperglycemia and insulin resistance1. Decline in β-cell function was seen in prediabetes due to metabolic and epigenetic changes and alterations at the level of its cellular biology (including transdifferentiation, endoplasmic reticulum stress, autophagy, and apoptosis), which leads to decreased availability of insulin and insulin-like growth factors in the system central nervous system, which regulate brain neuroplasticity and neurogenesis2. patients with prediabetes showed lower performance in neurocognitive tests and this has been associated with the onset of cognitive impairment1.Cognitive impairment begins with subtle, slow and progressive cognitive declines, more severe in older adults (AM) (≥65 years). This state of decline and loss of function Higher mental health is not an inevitable consequence of getting older. Many nonagenarians and centenarians have their cognitive functions preserved and in the “Study of autopsies of people age 90+ based on US population.” Almost half of the people with dementia did not have sufficient neuropathological evidence to explain their cognitive symptoms3.
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