Probiotics, Prebiotics, Synbiotics, and Paraprobiotics as a Therapeutic Alternative for Intestinal Mucositis
2020
Viviane Lima Batista | Tales Fernando da Silva | Luís Cláudio Lima de Jesus | Nina Dias Coelho-Rocha | Fernanda Alvarenga Lima Barroso | Laisa Macedo Tavares | Vasco Azevedo | Pamela Mancha-Agresti | Pamela Mancha-Agresti | Mariana Martins Drumond | Mariana Martins Drumond
Intestinal mucositis, a cytotoxic side effect of the antineoplastic drug 5-fluorouracil (5-FU), is characterized by ulceration, inflammation, diarrhea, and intense abdominal pain, making it an important issue for clinical medicine. Given the seriousness of the problem, therapeutic alternatives have been sought as a means to ameliorate, prevent, and treat this condition. Among the alternatives available to address this side effect of treatment with 5-FU, the most promising has been the use of probiotics, prebiotics, synbiotics, and paraprobiotics. This review addresses the administration of these “biotics” as a therapeutic alternative for intestinal mucositis caused by 5-FU. It describes the effects and benefits related to their use as well as their potential for patient care.
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