Advanced strategies for constructing interfacial tissues of bone and tendon/ligament
2022
Wangwang Luo | Yang Wang | Qing Han | Zhonghan Wang | Jianhang Jiao | Xuqiang Gong | Yang Liu | Aobo Zhang | Han Zhang | Hao Chen | Jincheng Wang | Minfei Wu
Enthesis, the interfacial tissue between a tendon/ligament and bone, exhibits a complex histological transition from soft to hard tissue, which significantly complicates its repair and regeneration after injury. Because traditional surgical treatments for enthesis injury are not satisfactory, tissue engineering has emerged as a strategy for improving treatment success. Rapid advances in enthesis tissue engineering have led to the development of several strategies for promoting enthesis tissue regeneration, including biological scaffolds, cells, growth factors, and biophysical modulation. In this review, we discuss recent advances in enthesis tissue engineering, particularly the use of biological scaffolds, as well as perspectives on the future directions in enthesis tissue engineering.
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