Synthesis of aromatic lactone analogues of Lipoxin A4
2022
Aya Ismael | Muhammad Zeeshan | Jørn H. Hansen
Abstract Objective Synthesis of novel aromatic Lipoxin A4 lactone analogues. Results Novel para-substituted aromatic lactone analogues of Lipoxin A4 have been synthesized in a convergent manner with six steps in the longest linear sequence in 12–13% yields, employing 2-deoxy-d-ribose as a chiral pool starting material and the classical E-selective Wittig olefination.
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