Unique Characteristics of Adipocytes in Metabolic Health: Insights and Implications
2024
Jeetendra Kumar Gupta | Yati Sharma | Nitin Wahi | Krishan Kumar
Adipocytes secrete a wide range of bioactive peptides known as adipokines. These factors play a crucial role in the complex network of metabolic control that connects adipose tissue activity with systemic metabolic balance. The intricacy of adipokine signalling networks and their relationships with other bodily metabolic regulators is also highlighted in this study. Although adipokines are necessary for healthy metabolism, the pathophysiology of various metabolic illnesses, such as obesity, type 2 diabetes, and cardiovascular diseases, are associated with their dysregulation. We explored the effects of changes in adipokine function and levels that affect various disorders, providing a detailed picture of the pathophysiology. This review also delves into the potential of adipokine as a metabolic illness biomarker, including its prognostic and diagnostic potential. Moreover, it assesses the potential therapeutic benefits of regulating adipokine activity and explores present and upcoming approaches to target these molecules to enhance metabolic health. Overall, This study emphasizes the many functions of adipokines in several metabolic processes, such as insulin sensitivity, lipid metabolism, glucose regulation, and inflammation. Additionally, it offers a comprehensive and insightful understanding of adipokines, emphasizing their pivotal role in metabolic well-being and disease.
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