BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways
2021
Yingnan Geng | Huichuan Duan | Liang Xu | Nevin Witman | Bingqian Yan | Zheyuan Yu | Huijing Wang | Yao Tan | Liqin Lin | Dong Li | Shanshan Bai | Regina Fritsche-Danielson | Jie Yuan | Kenneth Chien | Min Wei | Wei Fu
Geng et al. evaluate bone marrow stem cell (BMSC)-based system to deliver modified RNAs of BMP-2 and VEGF to enhance bone regeneration. They test its therapeutic efficacy in vivo on a rat skull defect model by inoculating these BMSCs in a collagen scaffold. This construct synergistically drives osteogenic and angiogenic pathways and can be a new approach for clinical treatment of bone injuries and defects.
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