Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas
2022
Alvin Wei Tian Ng | Gianmarco Contino | Sarah Killcoyne | Ginny Devonshire | Ray Hsu | Sujath Abbas | Jing Su | Aisling M. Redmond | Jamie M. J. Weaver | Matthew D. Eldridge | Simon Tavaré | Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium | Paul A. W. Edwards | Rebecca C. Fitzgerald
Genomic structural variants (SVs) in cancer are notoriously difficult to identify, despite the impact they have on cancer progression and treatment efficacy. This study applies state-of-the-art computational methods to catalogue SVs in 383 cases of oesophageal cancer, uncovering mutational patterns and new disease drivers.
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