NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance
2022
Rose Hodgson | Xijin Xu | Consuelo Anzilotti | Mukta Deobagkar-Lele | Tanya L. Crockford | Jessica D. Kepple | Eleanor Cawthorne | Aneesha Bhandari | Alberto Cebrian-Serrano | Martin J. Wilcock | Benjamin Davies | Richard J. Cornall | Katherine R. Bull
Despite an upregulation in anergic B cells, N-myc downstream-regulated gene 1 (NDRG1) is not required for the tolerogenic downstream responses, reducing risk of immune modulation on targeting of NDRG1 for cancer therapeutics.
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