Improvement of Antarctic krill oil on reserpine induced zebrafish depression model
2023
GUO Meng-jie | LIU Yun | WU Zhi-qiang | JIANG Guo-liang
<b>Objective:</b> This study aimed to investigate the effect of Antarctic krill oil on zebrafish model of depression. <b>Methods:</b> The zebrafish (<i>Danio rerio</i>) model of depression was induced by 40 mg/L reserpine, and five groups, i.e., blank control group, model group, fluoxetine group, low-dose krill oil group and high-dose krill oil group were investigated and compared, buy using new tank test (NTT) and light dark box test (LDB). The central nervous system serotonin (5-HT), dopamine (DA), monoamine oxidase A (MAO-A) Interleukin-6 (IL-6), tumor necrosis factor <i>α</i> (TNF-<i>α</i>) and systemic cortisol (COR) levels of the five groups were analyzed. <b>Results:</b> Reserpine 40 mg/L caused depressive behavior in zebrafish, while the addition of prawn oil reduced the this behavior, by increasing the levels of monoamine neurotransmitters including 5-HT and DA in the brain and decreasing the levels of MAO-A, IL-6 and TNF-<i>α</i> proinflammatory factors and systemic COR levels. <b>Conclusion:</b> Antarctic krill oil can improve the depression of zebrafish by reducing neuroinflammation and regulating neuroendocrine.
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